利用全国健康保险服务索赔数据分析韩国的成骨不全症:倾向得分匹配研究》。

IF 3.3 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM
Calcified Tissue International Pub Date : 2024-12-01 Epub Date: 2024-08-16 DOI:10.1007/s00223-024-01274-5
Sin Hyung Park, Ho Yoon, Siyeong Yoon, Jaiwoo Chung, Jae-Hyun Kim, Soonchul Lee
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引用次数: 0

摘要

成骨不全症(OI)是最常见的遗传性骨脆性疾病,包括一组不同的遗传疾病,最常见的是与 I 型胶原相关的缺陷导致的骨脆性。虽然已经开展了基因分析,但还缺乏对 OI 发病率和相关骨折的全国性研究。本研究旨在利用韩国国民健康保险服务(NHIS)的理赔数据,调查韩国的 OI 患病率、发病率、骨折率等模式。我们发现在 2002 年 3 月至 2020 年 2 月期间有 1596 名新诊断为 OI 的患者。我们评估了患者的发病率、患病率、骨折史、骨折部位、抗骨质疏松药物处方等。为了比较医疗费用、骨折率和脊柱侧弯率,我们采用 1:1 倾向评分匹配法建立了一个由无 OI 患者组成的对照组。OI的发病率每年略有上升,年发病率为每10万活产20.20例。OI患者的平均骨折频率为17(2-32)次/人,最常见的骨折部位是小腿。共有 21.4% 的患者服用了抗骨质疏松症药物,其中最常用的药物是帕米膦酸钠。经过 1:1 倾向评分匹配后,就脊柱侧弯而言,骨质疏松症患者的脊柱侧弯发生率是健康患者的 3.91 倍,具有统计学意义。OI患者的医疗费用总和是非OI患者的3.5倍。我们发现了全国范围内的 OI 发生率、骨折和药物使用趋势。这项研究还强调了与对照组相比,脊柱侧弯和医疗费用的真实世界数据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Analyses of Osteogenesis Imperfecta in South Korea Using the Nationwide Health Insurance Service Claim Data: A Propensity Score-Matched Study.

Analyses of Osteogenesis Imperfecta in South Korea Using the Nationwide Health Insurance Service Claim Data: A Propensity Score-Matched Study.

Osteogenesis imperfecta (OI) is the most common inherited form of bone fragility and includes a heterogeneous group of genetic disorders that most commonly result from defects associated with type I collagen. Although genetic analyses have been developed, nationwide research on the incidence and associated fractures in OI is lacking. This study aimed to investigate the patterns of OI prevalence, incidence, fracture rate, etc. in South Korea using National Health Insurance Service (NHIS) claims data. We found 1596 patients newly diagnosed with OI between March 2002 and February 2020. We evaluated the incidence, prevalence, and history of fractures, fracture site, prescription of anti-osteoporosis drugs, etc. To compare medical costs, fracture rates, and scoliosis rates, we created a control group comprising patients without OI using 1:1 propensity score matching. The prevalence of OI increased slightly each year, with an annual incidence of 20.20 per 100,000 live births. Mean fracture frequency in OI patients was 17 (2-32) times per patient and the most frequent fracture site was the lower leg. A total of 21.4% patients were prescribed anti-osteoporosis drugs, and the most popular drug was pamidronate. After 1:1 propensity score matching, in terms of scoliosis, OI patients had a 3.91 times higher prevalence of scoliosis than in healthy patients which was statistically significant. The sum of medical care expenses for patients with OI was 3.5 times higher than that for patients without OI. We identified nationwide trends in OI occurrence, fractures, and medication use. This study also highlighted the real-world data of scoliosis and medical costs compared to the control group.

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来源期刊
Calcified Tissue International
Calcified Tissue International 医学-内分泌学与代谢
CiteScore
8.00
自引率
2.40%
发文量
112
审稿时长
4-8 weeks
期刊介绍: Calcified Tissue International and Musculoskeletal Research publishes original research and reviews concerning the structure and function of bone, and other musculoskeletal tissues in living organisms and clinical studies of musculoskeletal disease. It includes studies of cell biology, molecular biology, intracellular signalling, and physiology, as well as research into the hormones, cytokines and other mediators that influence the musculoskeletal system. The journal also publishes clinical studies of relevance to bone disease, mineral metabolism, muscle function, and musculoskeletal interactions.
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