Jonas Dohmen, Nils Sommer, Katrin van Beekum, Jacob Nattermann, Christoph Engel, Jörg C Kalff, Robert Hüneburg, Tim O Vilz
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引用次数: 0
摘要
背景：林奇综合征（LS）是最常见的遗传性肿瘤综合征，与结直肠癌（CRC）发病风险增加有关。虽然在监测患者时考虑到了基因特异性和年龄特异性差异，但许多研究都报道了不同性别患 CRC 的风险，但没有一致的记录：本系统综述旨在研究 LS 患者中发生 CRC 的性别差异：按照 PRISMA 2020 指南，在 PubMed、Ovid、The Cochrane Library 和 Web of Science 数据库中进行了系统性文献检索。共筛选出 688 项研究，其中 41 项符合纳入标准：结果：与女性相比，男性罹患 CRC 的风险更高，发病时间更早：这些研究结果表明，LS 患者罹患 CRC 的风险存在性别差异，但目前还不能证明有必要采取单独的监控策略。
[Gender-specific differences in the development of colorectal cancer in Lynch syndrome patients-A systematic review].
Background: Lynch syndrome (LS) is the most frequent hereditary tumor syndrome and is associated with an increased risk of colorectal cancer (CRC). While gene-specific and age-specific differences are considered in patient surveillance, gender-specific risks in the development of CRC have been reported in many studies but are not consistently documented.
Objective: This systematic review aims to investigate gender-specific differences in CRC development among LS patients.
Material and methods: A systematic literature search following PRISMA 2020 guidelines was conducted in the PubMed, Ovid, The Cochrane Library and Web of Science databases. A total of 688 studies were screened, and 41 met the inclusion criteria.
Results: Men have a higher risk of CRC and develop CRC earlier compared to women.
Conclusion: These findings indicate gender-specific differences in the risk of CRC among LS patients, although they do not currently justify separate surveillance strategies.
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