封面：用于光药理学研究的基因定向笼型 RyR 探针的设计、合成和光化学特性（ChemPhotoChem 8/2024）

IF 3 4区化学 Q3 CHEMISTRY, PHYSICAL

ChemPhotoChem Pub Date : 2024-08-13 DOI:10.1002/cptc.202480801

Aika Yokoyama, Hanami Aoki, Mizuki Funayama, Ryo Shinozaki, Hiroto Yoshida, Dr. Akinobu Z. Suzuki, Prof. Dr. Toshiaki Furuta

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引用次数: 0

摘要

封面展示了香豆素笼型雷诺丁受体（RyR）激动剂和阻断剂的分子结构。光照射（6-溴-7-羟基香豆素-4-基）甲基（Bhc）笼状激动剂可释放出活性形式，激活 RyR，并促进哺乳动物细胞内质网释放 Ca2+。酶底物掩盖了笼型 RyR 探针在 405 纳米光下的光活性，从而实现了笼型 RyR 探针的细胞类型选择性酶基因定向传递。更多信息请参阅 A. Yokoyama、H. Aoki、T. Furuta 等人的研究文章（DOI 10.1002/cptc.202400140）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Front Cover: Design, Synthesis, and Photochemical Properties of Gene-directed Caged RyR Probes for Photopharmacological Studies (ChemPhotoChem 8/2024)

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Front Cover: Design, Synthesis, and Photochemical Properties of Gene-directed Caged RyR Probes for Photopharmacological Studies (ChemPhotoChem 8/2024)

The Front Cover illustrates the molecular structures of coumarin-caged ryanodine receptor (RyR) agonists and blockers. Photo-irradiation of a (6-bromo-7-hydroxycoumarin-4-yl)methyl (Bhc)-caged agonist released the active form, activated RyRs, and promoted Ca²⁺ release from the endoplasmic reticulum in mammalian cells. The photoreactivity of the caged RyR probes by 405 nm light was masked by the enzyme substrates, allowing cell-type-selective, enzyme gene-directed delivery of the caged RyR probes. More information can be found in the Research Article by A. Yokoyama, H. Aoki, T. Furuta et al. (DOI 10.1002/cptc.202400140).

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来源期刊

ChemPhotoChem Chemistry-Physical and Theoretical Chemistry

CiteScore

5.80

自引率

5.40%

发文量

165

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