[IV期肺癌伴有低度持续性或低度浸润性疾病的局部治疗]

IF 0.5 4区 医学 Q4 SURGERY
Zentralblatt fur Chirurgie Pub Date : 2024-08-01 Epub Date: 2024-08-13 DOI:10.1055/a-2351-4358
Christian Schulz
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引用次数: 0

摘要

少转移和少进展性疾病被定义为转移性肺癌的两种不同情况。少转移持续是指经过有效的全身治疗后,仍有数量有限的转移灶存在。寡进展则是指肿瘤病情基本得到控制,只有少数转移灶出现明显进展。在少进展期,治疗的目的是完全控制肿瘤,并通过对所有剩余病灶进行局部消融治疗来改善预后。在少进展的情况下,局部消融治疗的目的是在继续全身治疗的同时,重新建立对肿瘤的完全控制。这些概念是基于赫尔曼和魏希塞尔鲍姆 30 多年前在肿瘤学中使用寡转移瘤这一术语时提出的观点。多模式疗法的概念在寡转移持续存在和寡转移进展的情况下变得越来越重要,特别是由于针对癌基因驱动的肺癌的分子靶向疗法以及具有高反应率和长反应持续时间的化疗免疫疗法。我们将通过案例研究来介绍和解释现有的证据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Local Therapy in Stage IV Lung Cancer with Oligopersistent or Oligoprogessive Disease].

Oligopersistent and oligoprogressive disease are defined as distinct situations of metastastatic lung cancer. Oligopersistence describes a situation in which a limited number of metastases remain following effective systemic therapy. Oligoprogression represents a largely controlled tumour disease with a few metastases showing significant progression. In the oligopersistence, treatment aims to establish complete tumour control with subsequent improvement of the prognosis by means of additional local ablative treatment of all remaining lesions. In the oligoprogressive situation, local ablative treatment aims to reestablish complete tumour control while continuing systemic therapy. The concepts are based on ideas that were introduced in oncology more than 30 years ago by Hellman and Weichselbaum by using the term oligometastases. Multimodal therapy concepts have gained importance in the situation of oligopersistence and oligoprogression, particularly due to molecular targeted therapies for oncogene-driven lung cancer and chemo-immunotherapy regimes with high response rates and long response duration. The available evidence will be presented and explained by case studies.

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来源期刊
CiteScore
1.00
自引率
14.30%
发文量
116
审稿时长
6-12 weeks
期刊介绍: Konzentriertes Fachwissen aus Forschung und Praxis Das Zentralblatt für Chirurgie – alle Neuigkeiten aus der Allgemeinen, Viszeral-, Thorax- und Gefäßchirurgie.
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