手术治疗对前列腺癌脊柱转移患者疗效的影响。

IF 1.5 4区 医学 Q3 ORTHOPEDICS
Ryosuke Hirota, Tsutomu Oshigiri, Noriyuki Iesato, Makoto Emori, Atsushi Teramoto, Yuki Shiratani, Akinobu Suzuki, Hidetomi Terai, Takaki Shimizu, Kenichiro Kakutani, Yutaro Kanda, Hiroyuki Tominaga, Ichiro Kawamura, Masayuki Ishihara, Masaaki Paku, Yohei Takahashi, Toru Funayama, Kousei Miura, Eiki Shirasawa, Hirokazu Inoue, Atsushi Kimura, Takuya Iimura, Hiroshi Moridaira, Hideaki Nakajima, Shuji Watanabe, Koji Akeda, Norihiko Takegami, Kazuo Nakanishi, Hirokatsu Sawada, Koji Matsumoto, Masahiro Funaba, Hidenori Suzuki, Haruki Funao, Takashi Hirai, Bungo Otsuki, Kazu Kobayakawa, Koji Uotani, Hiroaki Manabe, Shinji Tanishima, Ko Hashimoto, Chizuo Iwai, Daisuke Yamabe, Akihiko Hiyama, Shoji Seki, Yuta Goto, Masashi Miyazaki, Kazuyuki Watanabe, Toshio Nakamae, Takashi Kaito, Hiroaki Nakashima, Narihito Nagoshi, Satoshi Kato, Shiro Imagama, Kota Watanabe, Gen Inoue, Takeo Furuya
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引用次数: 0

摘要

研究目的本研究旨在阐明前列腺癌脊柱转移患者的术后效果,重点关注以患者为导向的评估:这是一项前瞻性多中心登记研究,涉及 35 个中心。共有 413 名患者参加了日本脊柱外科和肿瘤协会的转移性脊柱肿瘤手术多中心前瞻性研究。符合条件的患者在术后接受了至少一年的随访。弗兰克尔分类、东部合作肿瘤学组表现状态、疼痛视觉模拟量表、面容量表、巴特尔指数、活力指数、口服止痛药适应症和EQ-5D-5L问卷用于评估功能状态、日常生活活动和患者动力:在 413 名符合条件的患者中,41 名原发性前列腺癌患者被纳入研究。以患者为导向的评估结果表明,患者术后的生活质量和积极性在大多数项目上都有所改善,改善持续时间长达 6 个月。弗兰克尔分级为B级或C级的患者中,半数以上在术后1个月神经功能有所改善,大多数患者在术后6个月保持或改善了他们的分级:结论:前列腺癌脊柱转移的手术治疗能显著改善患者的神经功能、生活质量和积极性。因此,我们的研究结果支持手术干预在改善前列腺癌脊柱转移患者的神经功能和整体健康方面的有效性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Impact of surgical treatment on patient reported outcome in patients with spinal metastases from prostate cancer.

Objective: This study aimed to elucidate postoperative outcomes in patients with spinal metastases of prostate cancer, with a focus on patient-oriented assessments.

Methods: This was a prospective multicenter registry study involving 35 centers. A total of 413 patients enrolled in the Japanese Association for Spine Surgery and Oncology Multicenter Prospective Study of Surgery for Metastatic Spinal Tumors were evaluated for inclusion. The eligible patients were followed for at least 1 year after surgery. The Frankel Classification, Eastern Cooperative Oncology Group Performance Status, visual analog scale for pain, face scale, Barthel Index, vitality index, indications for oral pain medication, and the EQ-5D-5L questionnaire were used for evaluating functional status, activities of daily living, and patient motivation.

Results: Of the 413 eligible patients, 41 with primary prostate cancer were included in the study. The patient-oriented assessments indicated that the patients experienced postoperative improvements in quality of life and motivation in most items, with the improvements extending for up to 6 months. More than half of the patients with Frankel classifications B or C showed improved neurological function at 1 month after surgery, and most patients presented maintained or improved their classification at 6 months.

Conclusion: Surgical intervention for spinal metastases of prostate cancer significantly improved neurological function, quality of life, and motivation of the patients. Consequently, our results support the validity of surgical intervention for improving the neurological function and overall well-being of patients with spinal metastases of prostate cancer.

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来源期刊
Journal of Orthopaedic Science
Journal of Orthopaedic Science 医学-整形外科
CiteScore
3.00
自引率
0.00%
发文量
290
审稿时长
90 days
期刊介绍: The Journal of Orthopaedic Science is the official peer-reviewed journal of the Japanese Orthopaedic Association. The journal publishes the latest researches and topical debates in all fields of clinical and experimental orthopaedics, including musculoskeletal medicine, sports medicine, locomotive syndrome, trauma, paediatrics, oncology and biomaterials, as well as basic researches.
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