群体遗传学:物理学家入门

Andrea Iglesias Ramas, Samuele Pio Lipani, Rosalind J. Allen
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摘要

群体遗传学是进化理论的核心。这一主题是许多生物科学课程的一部分,但很少向物理系学生讲授。由于物理学家对生物进化的兴趣与日俱增,我们旨在为物理学家简要介绍种群遗传学。我们从两个背景章节开始:第 1 章简要介绍了这一主题的历史,而第 2 章则提供了一些基本的生物学背景。我们的主要内容从第 3 章开始,该章讨论了达尔文自然选择和孟德尔遗传背后的关键概念。第 4 章介绍了变异如何在种群中得以维持的基础知识,第 5 章讨论了变异和选择。在第 6 章中,我们以赖特-费舍模型为例,讨论了种群遗传学中的随机效应。最后,我们在第 7 章中提出了结束语和优秀教科书参考文献。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Population genetics: an introduction for physicists
Population genetics lies at the heart of evolutionary theory. This topic forms part of many biological science curricula but is rarely taught to physics students. Since physicists are becoming increasingly interested in biological evolution, we aim to provide a brief introduction to population genetics, written for physicists. We start with two background chapters: chapter 1 provides a brief historical introduction to the topic, while chapter 2 provides some essential biological background. We begin our main content with chapter 3 which discusses the key concepts behind Darwinian natural selection and Mendelian inheritance. Chapter 4 covers the basics of how variation is maintained in populations, while chapter 5 discusses mutation and selection. In chapter 6 we discuss stochastic effects in population genetics using the Wright-Fisher model as our example, and finally we offer concluding thoughts and references to excellent textbooks in chapter 7.
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