炎症和结直肠癌中的肠道微生物群：临床医生的潜在工具箱

IF 3.2 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Best Practice & Research Clinical Gastroenterology Pub Date : 2024-07-31 DOI:10.1016/j.bpg.2024.101942

Nathan Grellier, Andrea Severino, Sebastiano Archilei, Jumin Kim, Antonio Gasbarrini, Giovanni Cammarota, Serena Porcari, Nicolas Benech

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引用次数: 0

摘要

大肠癌（CRC）是一个全球性的公共健康问题，尤其是与西方生活方式相关的慢性病患者，如代谢性疾病和炎症性肠病（IBD）。有趣的是，代谢性疾病和炎症性肠病都以慢性炎症状态为特征，而慢性炎症会导致肠道微生物群的组成和功能发生特定的改变，从而诱发癌变。现在有证据表明，肠道微生物群的改变会助长慢性促炎症状态，形成恶性循环，从而有利于 CRC 的发展。在这篇综述文章中，我们介绍了目前有关肠道微生物群作为肠道疾病和心脏代谢疾病共同的致癌因素的知识，并提供了如何利用肠道微生物群预防或诊断 CRC 的线索。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Gut microbiota in inflammation and colorectal cancer: A potential Toolbox for Clinicians

Colorectal cancer (CRC) is a worldwide public health issue specifically in patients with chronic diseases associated with a western lifestyle, such as metabolic diseases and inflammatory bowel diseases (IBD). Interestingly, both metabolic disorders and IBD are characterized by a chronic state of inflammation that contributes to the carcinogenesis with specific alteration of the gut microbiota composition and function. Evidence now shows that this altered gut microbiota contributes fueling a chronic pro-inflammatory state in a vicious circle that can favor CRC development. In this review article, we present the current knowledge concerning the involvement of the gut microbiota as a procarcinogenic factor shared by IBD and cardiometabolic diseases, and provide clues as to how it may be used to prevent or diagnose CRC.

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来源期刊

Best Practice & Research Clinical Gastroenterology 医学-胃肠肝病学

CiteScore

5.50

自引率

0.00%

发文量

审稿时长

69 days

期刊介绍： Each topic-based issue of Best Practice & Research Clinical Gastroenterology will provide a comprehensive review of current clinical practice and thinking within the specialty of gastroenterology.