Manish Sarkar, Henning von Horsten, Dimitrije Milunov, Nathalie Barreto Lefebvre, Soham Saha
{"title":"遗传性肥胖症的临床疗效景观:对普拉德-威利综合征(PWS)的荟萃分析","authors":"Manish Sarkar, Henning von Horsten, Dimitrije Milunov, Nathalie Barreto Lefebvre, Soham Saha","doi":"10.1101/2024.08.02.24311335","DOIUrl":null,"url":null,"abstract":"Genetic obesity such as Prader Willi syndrome (PWS) is a multifaceted condition influenced by various elements, including genetic predisposition, environmental factors, and behavioral components. This meta-analysis explored the reported efficacy of therapeutics in clinical trials for PWS by evaluating clinical endpoints reached in the course of the study and the adverse events observed for each. We looked at GLP1 receptor mediated and non-GLP1 receptor mediated therapies and compared their performance in study arms across time and standard of care. In addition, we estimated the present market shares across different obesity and diabetes assets. In conclusion, the study points to two key readouts. First, existing obesity and diabetes assets are not effective for genetic obesity such as PWS. The unmet needs remain high. Second, the market of obesity and diabetes are in a stage of expansion. A collaborative approach to therapy development for genetic obesity is required to improve the quality of life for affected individuals.","PeriodicalId":501276,"journal":{"name":"medRxiv - Public and Global Health","volume":"29 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Clinical efficacy landscaping in genetic obesity: A meta-analysis in Prader Willi syndrome (PWS)\",\"authors\":\"Manish Sarkar, Henning von Horsten, Dimitrije Milunov, Nathalie Barreto Lefebvre, Soham Saha\",\"doi\":\"10.1101/2024.08.02.24311335\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Genetic obesity such as Prader Willi syndrome (PWS) is a multifaceted condition influenced by various elements, including genetic predisposition, environmental factors, and behavioral components. This meta-analysis explored the reported efficacy of therapeutics in clinical trials for PWS by evaluating clinical endpoints reached in the course of the study and the adverse events observed for each. We looked at GLP1 receptor mediated and non-GLP1 receptor mediated therapies and compared their performance in study arms across time and standard of care. In addition, we estimated the present market shares across different obesity and diabetes assets. In conclusion, the study points to two key readouts. First, existing obesity and diabetes assets are not effective for genetic obesity such as PWS. The unmet needs remain high. Second, the market of obesity and diabetes are in a stage of expansion. A collaborative approach to therapy development for genetic obesity is required to improve the quality of life for affected individuals.\",\"PeriodicalId\":501276,\"journal\":{\"name\":\"medRxiv - Public and Global Health\",\"volume\":\"29 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-08-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"medRxiv - Public and Global Health\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1101/2024.08.02.24311335\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"medRxiv - Public and Global Health","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1101/2024.08.02.24311335","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Clinical efficacy landscaping in genetic obesity: A meta-analysis in Prader Willi syndrome (PWS)
Genetic obesity such as Prader Willi syndrome (PWS) is a multifaceted condition influenced by various elements, including genetic predisposition, environmental factors, and behavioral components. This meta-analysis explored the reported efficacy of therapeutics in clinical trials for PWS by evaluating clinical endpoints reached in the course of the study and the adverse events observed for each. We looked at GLP1 receptor mediated and non-GLP1 receptor mediated therapies and compared their performance in study arms across time and standard of care. In addition, we estimated the present market shares across different obesity and diabetes assets. In conclusion, the study points to two key readouts. First, existing obesity and diabetes assets are not effective for genetic obesity such as PWS. The unmet needs remain high. Second, the market of obesity and diabetes are in a stage of expansion. A collaborative approach to therapy development for genetic obesity is required to improve the quality of life for affected individuals.