有美沙酮维持治疗史的患者中央叶旁的脑血流量与主观睡眠质量差有关

Jiaxue Sun, Yi Lu, Deshenyue Kong, Wenhua Lin, Jinze Du, Guangqing Wang, Xingfeng Ma, Congbin Li, Kunhua Wang, Mei Zhu, Yu Xu
{"title":"有美沙酮维持治疗史的患者中央叶旁的脑血流量与主观睡眠质量差有关","authors":"Jiaxue Sun, Yi Lu, Deshenyue Kong, Wenhua Lin, Jinze Du, Guangqing Wang, Xingfeng Ma, Congbin Li, Kunhua Wang, Mei Zhu, Yu Xu","doi":"10.3389/fneur.2024.1400810","DOIUrl":null,"url":null,"abstract":"Sleep disorders are prevalent and significant among individuals receiving methadone maintenance treatment (MMT), adversely affecting their quality of life and treatment adherence. While cerebral blood flow (CBF) plays a crucial role in the development of various diseases, its relationship with sleep disorders remains uncertain. This observational study focuses on possible correlations between CBF and poor subjective sleep quality in MMT patients.A total of 75 participants with a history of MMT were recruited and assessed using pseudo-continuous arterial spin labeling magnetic resonance imaging to determine CBF. A LAASO regression model was employed to identify the region of interest (ROI) most associated with sleep disturbance. The association between the CBF of the ROI and the Pittsburgh Sleep Quality Index (PSQI) was examined using regression analyses. Age, gender, BMI, history of hypertension, diabetes, hyperlipidemia, and methadone withdrawal were included as covariates.Among MMT patients with poor subjective sleep quality, significantly higher CBF was observed in the right paracentral lobule (56.1057 ± 11.1624 ml/100 g/min, p = 0.044), right cerebelum_3 (56.6723 ± 15.3139 ml/100 g/min, p = 0.026), right caudate nucleus (48.9168 ± 6.9910 ml/100 g/min, p = 0.009), and left caudate nucleus (47.6207 ± 6.1374 ml/100 g/min, p = 0.006). Furthermore, a positive correlation was found between CBF in the right paracentral lobule and the total PSQI score (β = 0.1135, p = 0.0323), with the association remaining significant even after adjustment for covariates (β = 0.1276, p = 0.0405).MMT patients with poor subjective sleep quality exhibited significantly altered CBF in multiple brain regions. The association between increased CBF in the right paracentral lobule and subjective sleep quality in MMT patients could be crucial in understanding sleep disorders in individuals undergoing MMT.https://www.chictr.org.cn/, identifier: ChiCTR2100051931.","PeriodicalId":503840,"journal":{"name":"Frontiers in Neurology","volume":"1 3","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Cerebral blood flow in the paracentral lobule is associated with poor subjective sleep quality among patients with a history of methadone maintenance treatment\",\"authors\":\"Jiaxue Sun, Yi Lu, Deshenyue Kong, Wenhua Lin, Jinze Du, Guangqing Wang, Xingfeng Ma, Congbin Li, Kunhua Wang, Mei Zhu, Yu Xu\",\"doi\":\"10.3389/fneur.2024.1400810\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Sleep disorders are prevalent and significant among individuals receiving methadone maintenance treatment (MMT), adversely affecting their quality of life and treatment adherence. While cerebral blood flow (CBF) plays a crucial role in the development of various diseases, its relationship with sleep disorders remains uncertain. This observational study focuses on possible correlations between CBF and poor subjective sleep quality in MMT patients.A total of 75 participants with a history of MMT were recruited and assessed using pseudo-continuous arterial spin labeling magnetic resonance imaging to determine CBF. A LAASO regression model was employed to identify the region of interest (ROI) most associated with sleep disturbance. The association between the CBF of the ROI and the Pittsburgh Sleep Quality Index (PSQI) was examined using regression analyses. Age, gender, BMI, history of hypertension, diabetes, hyperlipidemia, and methadone withdrawal were included as covariates.Among MMT patients with poor subjective sleep quality, significantly higher CBF was observed in the right paracentral lobule (56.1057 ± 11.1624 ml/100 g/min, p = 0.044), right cerebelum_3 (56.6723 ± 15.3139 ml/100 g/min, p = 0.026), right caudate nucleus (48.9168 ± 6.9910 ml/100 g/min, p = 0.009), and left caudate nucleus (47.6207 ± 6.1374 ml/100 g/min, p = 0.006). Furthermore, a positive correlation was found between CBF in the right paracentral lobule and the total PSQI score (β = 0.1135, p = 0.0323), with the association remaining significant even after adjustment for covariates (β = 0.1276, p = 0.0405).MMT patients with poor subjective sleep quality exhibited significantly altered CBF in multiple brain regions. The association between increased CBF in the right paracentral lobule and subjective sleep quality in MMT patients could be crucial in understanding sleep disorders in individuals undergoing MMT.https://www.chictr.org.cn/, identifier: ChiCTR2100051931.\",\"PeriodicalId\":503840,\"journal\":{\"name\":\"Frontiers in Neurology\",\"volume\":\"1 3\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-08-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Frontiers in Neurology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3389/fneur.2024.1400810\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Neurology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3389/fneur.2024.1400810","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

睡眠障碍在接受美沙酮维持治疗(MMT)的患者中十分普遍和严重,对他们的生活质量和坚持治疗产生了不利影响。虽然脑血流量(CBF)在各种疾病的发展中起着至关重要的作用,但其与睡眠障碍的关系仍不确定。这项观察性研究主要探讨了MMT患者的CBF与主观睡眠质量差之间可能存在的相关性。研究人员共招募了75名有MMT病史的患者,并使用假连续动脉自旋标记磁共振成像技术对其进行评估,以确定CBF。采用 LAASO 回归模型确定与睡眠障碍最相关的感兴趣区(ROI)。通过回归分析研究了感兴趣区 CBF 与匹兹堡睡眠质量指数(PSQI)之间的关系。在主观睡眠质量较差的 MMT 患者中,右侧中央小叶旁的 CBF 明显较高(56.1057 ± 11.1624 ml/100 g/min,p = 0.044)、右侧大脑3(56.6723 ± 15.3139 ml/100 g/min,p = 0.026)、右侧尾状核(48.9168 ± 6.9910 ml/100 g/min,p = 0.009)和左侧尾状核(47.6207 ± 6.1374 ml/100 g/min,p = 0.006)的 CBF 明显更高。此外,还发现右侧中央小叶旁的 CBF 与 PSQI 总分之间存在正相关(β = 0.1135,p = 0.0323),即使在调整协变量(β = 0.1276,p = 0.0405)后,两者之间的相关性仍然显著。MMT患者右侧中央小叶旁CBF增加与主观睡眠质量之间的关联可能对了解MMT患者的睡眠障碍至关重要。https://www.chictr.org.cn/,标识符:ChiCTR2100051931。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cerebral blood flow in the paracentral lobule is associated with poor subjective sleep quality among patients with a history of methadone maintenance treatment
Sleep disorders are prevalent and significant among individuals receiving methadone maintenance treatment (MMT), adversely affecting their quality of life and treatment adherence. While cerebral blood flow (CBF) plays a crucial role in the development of various diseases, its relationship with sleep disorders remains uncertain. This observational study focuses on possible correlations between CBF and poor subjective sleep quality in MMT patients.A total of 75 participants with a history of MMT were recruited and assessed using pseudo-continuous arterial spin labeling magnetic resonance imaging to determine CBF. A LAASO regression model was employed to identify the region of interest (ROI) most associated with sleep disturbance. The association between the CBF of the ROI and the Pittsburgh Sleep Quality Index (PSQI) was examined using regression analyses. Age, gender, BMI, history of hypertension, diabetes, hyperlipidemia, and methadone withdrawal were included as covariates.Among MMT patients with poor subjective sleep quality, significantly higher CBF was observed in the right paracentral lobule (56.1057 ± 11.1624 ml/100 g/min, p = 0.044), right cerebelum_3 (56.6723 ± 15.3139 ml/100 g/min, p = 0.026), right caudate nucleus (48.9168 ± 6.9910 ml/100 g/min, p = 0.009), and left caudate nucleus (47.6207 ± 6.1374 ml/100 g/min, p = 0.006). Furthermore, a positive correlation was found between CBF in the right paracentral lobule and the total PSQI score (β = 0.1135, p = 0.0323), with the association remaining significant even after adjustment for covariates (β = 0.1276, p = 0.0405).MMT patients with poor subjective sleep quality exhibited significantly altered CBF in multiple brain regions. The association between increased CBF in the right paracentral lobule and subjective sleep quality in MMT patients could be crucial in understanding sleep disorders in individuals undergoing MMT.https://www.chictr.org.cn/, identifier: ChiCTR2100051931.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信