作为配子氧化应激、生育能力和潜在试管婴儿结果生物标志物的端粒和 SIRT1

IF 4.9 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

International Journal of Molecular Sciences Pub Date : 2024-08-08 DOI:10.3390/ijms25168652

Anna Pańczyszyn, E. Boniewska-Bernacka, I. Wertel, Anna Sadakierska-Chudy, Anna Goc

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引用次数: 0

摘要

接受体外受精（IVF）的不孕夫妇数量大幅增加。这一过程的有效性取决于多种因素，包括配子质量。影响配子质量的一个因素是氧化应激，它会导致端粒损伤并加速细胞老化。找出能预测辅助生殖技术成功与否的新生物标志物是当前的一个相关研究领域。在这篇综述中，我们将讨论 SIRT1 作为配子质量和辅助生殖技术结果的生物标志物的潜在作用，SIRT1 是一种已知能防止氧化应激的蛋白质，而端粒则负责基因组的稳定性。

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Telomeres and SIRT1 as Biomarkers of Gamete Oxidative Stress, Fertility, and Potential IVF Outcome

The number of infertile couples undergoing in vitro fertilisation (IVF) has increased significantly. The efficacy of this procedure is contingent upon a multitude of factors, including gamete quality. One factor influencing gamete quality is oxidative stress, which leads to telomere damage and accelerates cellular ageing. Identifying new biomarkers that can predict the success of assisted reproduction techniques is a current relevant area of research. In this review, we discuss the potential role of SIRT1, a protein known to protect against oxidative stress and telomeres, which are responsible for genome stability, as biomarkers of gamete quality and assisted reproduction technique outcomes.

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来源期刊

International Journal of Molecular Sciences Chemistry-Organic Chemistry

CiteScore

8.10

自引率

10.70%

发文量

13472

审稿时长

17.49 days

期刊介绍： The International Journal of Molecular Sciences (ISSN 1422-0067) provides an advanced forum for chemistry, molecular physics (chemical physics and physical chemistry) and molecular biology. It publishes research articles, reviews, communications and short notes. Our aim is to encourage scientists to publish their theoretical and experimental results in as much detail as possible. Therefore, there is no restriction on the length of the papers or the number of electronics supplementary files. For articles with computational results, the full experimental details must be provided so that the results can be reproduced. Electronic files regarding the full details of the calculation and experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material (including animated pictures, videos, interactive Excel sheets, software executables and others).