孤立的生长激素缺乏症

A. Ibba, C. Guzzetti, Lavinia Sanfilippo, Sandro Loche
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引用次数: 0

摘要

生长激素缺乏症(GHD)是儿童时期最常见的垂体激素缺乏症,发病率为每4000-10000名活产婴儿中就有1例。生长激素缺乏症可以是先天性的(遗传或下丘脑/垂体异常所致),也可以是后天获得的,可以是孤立的(IGHD),也可以与其他垂体激素缺乏症伴发,但大多数病例是特发性的。GH 刺激试验通常用于 GHD 的诊断工作,但某些临床病症无需进行 GH 刺激试验即可确诊。GHD患儿接受每日注射重组人GH(rhGH)的替代治疗。RhGH 疗法能有效提高 GHD 患者的短期身高增长和成年身高。许多大型国际研究都证实了长期 GH 治疗的安全性。最近,长效每周 GH 制剂问世,显示出良好的疗效和安全性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Isolated Growth Hormone Deficiency
Growth hormone deficiency (GHD) is the most frequent pituitary hormone deficiency in childhood, with an incidence of 1 in 4000–10,000 live births. GHD can be congenital (genetic or due to hypothalamic/pituitary abnormalities) or acquired and can be isolated (IGHD) or associated with other pituitary hormone deficiencies, but most cases are idiopathic. GH stimulation testing is commonly used in the diagnostic workup of GHD, except for some clinical conditions that do not require GH stimulation tests for the diagnosis. Children with GHD receive replacement therapy with daily injections of recombinant human GH (rhGH). RhGH therapy is effective in increasing short-term height gain and adult height in patients with GHD. The safety of long term GH therapy has been confirmed in many large international studies. Recently, long-acting weekly GH formulations have been introduced, showing good efficacy and safety profiles.
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