Peter M. George, C. Rennison-Jones, Giacomo Benvenuti, Aliki Sifostratoudaki, F. Ottink, W. Bou-Zeid, Roberta Eufrasia Ledda, Roqia Fatmawati, Abul Kadir, Bushra Johari, C. Fernandez, G. Harston, O. Joly, S. Gerry, A. Devaraj
{"title":"评估特发性肺纤维化中的 e-Lung 自动定量 CT 生物标记物","authors":"Peter M. George, C. Rennison-Jones, Giacomo Benvenuti, Aliki Sifostratoudaki, F. Ottink, W. Bou-Zeid, Roberta Eufrasia Ledda, Roqia Fatmawati, Abul Kadir, Bushra Johari, C. Fernandez, G. Harston, O. Joly, S. Gerry, A. Devaraj","doi":"10.1183/23120541.00570-2024","DOIUrl":null,"url":null,"abstract":"In patients with idiopathic pulmonary fibrosis (IPF), there is a need to identify biomarkers that i) are associated with increased risk of adverse outcome and ii) can be used to monitor treatment response or identify disease progression over time.Two consecutive cohorts of patients with IPF were accessed from the Open Source Imaging Consortium database. Automated CT biomarkers of disease severity incorporating fibrotic and pulmonary vascular features (the reticulovascular score and weighted reticulovascular score (WRVS)), were studied. Relationships between imaging biomarkers, lung function and survival were analysed.In separate test and validation cohorts, 168 and 176 patients with IPF respectively (median survival 2.6 years) were studied. A threshold of WRVS ≥15% at baseline CT was most strongly associated with transplant free survival (HR 3.00, 95% CI 1.47, 6.10, p=0.002) when adjusted for baseline FVC and age. In patients with 12 month follow up CT and lung function tests (n=89) an increase in 3% of WRVS (the minimal clinically important difference) was also significantly associated with reduced survival independent of FVC, and outperformed visual evaluation of progressive fibrosis.WRVS is an automated CT biomarker which can identify patients with IPF at increased risk of progression and is able to reliably capture disease progression over time.","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":null,"pages":null},"PeriodicalIF":4.3000,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Evaluation of e-Lung automated quantitative CT biomarkers in idiopathic pulmonary fibrosis\",\"authors\":\"Peter M. George, C. Rennison-Jones, Giacomo Benvenuti, Aliki Sifostratoudaki, F. Ottink, W. Bou-Zeid, Roberta Eufrasia Ledda, Roqia Fatmawati, Abul Kadir, Bushra Johari, C. Fernandez, G. Harston, O. Joly, S. Gerry, A. Devaraj\",\"doi\":\"10.1183/23120541.00570-2024\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"In patients with idiopathic pulmonary fibrosis (IPF), there is a need to identify biomarkers that i) are associated with increased risk of adverse outcome and ii) can be used to monitor treatment response or identify disease progression over time.Two consecutive cohorts of patients with IPF were accessed from the Open Source Imaging Consortium database. Automated CT biomarkers of disease severity incorporating fibrotic and pulmonary vascular features (the reticulovascular score and weighted reticulovascular score (WRVS)), were studied. Relationships between imaging biomarkers, lung function and survival were analysed.In separate test and validation cohorts, 168 and 176 patients with IPF respectively (median survival 2.6 years) were studied. A threshold of WRVS ≥15% at baseline CT was most strongly associated with transplant free survival (HR 3.00, 95% CI 1.47, 6.10, p=0.002) when adjusted for baseline FVC and age. In patients with 12 month follow up CT and lung function tests (n=89) an increase in 3% of WRVS (the minimal clinically important difference) was also significantly associated with reduced survival independent of FVC, and outperformed visual evaluation of progressive fibrosis.WRVS is an automated CT biomarker which can identify patients with IPF at increased risk of progression and is able to reliably capture disease progression over time.\",\"PeriodicalId\":11739,\"journal\":{\"name\":\"ERJ Open Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.3000,\"publicationDate\":\"2024-08-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ERJ Open Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1183/23120541.00570-2024\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"RESPIRATORY SYSTEM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ERJ Open Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1183/23120541.00570-2024","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"RESPIRATORY SYSTEM","Score":null,"Total":0}
Evaluation of e-Lung automated quantitative CT biomarkers in idiopathic pulmonary fibrosis
In patients with idiopathic pulmonary fibrosis (IPF), there is a need to identify biomarkers that i) are associated with increased risk of adverse outcome and ii) can be used to monitor treatment response or identify disease progression over time.Two consecutive cohorts of patients with IPF were accessed from the Open Source Imaging Consortium database. Automated CT biomarkers of disease severity incorporating fibrotic and pulmonary vascular features (the reticulovascular score and weighted reticulovascular score (WRVS)), were studied. Relationships between imaging biomarkers, lung function and survival were analysed.In separate test and validation cohorts, 168 and 176 patients with IPF respectively (median survival 2.6 years) were studied. A threshold of WRVS ≥15% at baseline CT was most strongly associated with transplant free survival (HR 3.00, 95% CI 1.47, 6.10, p=0.002) when adjusted for baseline FVC and age. In patients with 12 month follow up CT and lung function tests (n=89) an increase in 3% of WRVS (the minimal clinically important difference) was also significantly associated with reduced survival independent of FVC, and outperformed visual evaluation of progressive fibrosis.WRVS is an automated CT biomarker which can identify patients with IPF at increased risk of progression and is able to reliably capture disease progression over time.
期刊介绍:
ERJ Open Research is a fully open access original research journal, published online by the European Respiratory Society. The journal aims to publish high-quality work in all fields of respiratory science and medicine, covering basic science, clinical translational science and clinical medicine. The journal was created to help fulfil the ERS objective to disseminate scientific and educational material to its members and to the medical community, but also to provide researchers with an affordable open access specialty journal in which to publish their work.