小胶质细胞决定了ß-淀粉样蛋白斑块的负担,但对下游病理过程并非必不可少

bioRxiv Pub Date : 2024-08-08 DOI:10.1101/2024.08.06.606795
Mosi Li, Kris Holt, Katherine Ridley, Jing Qiu, Kirsty Haddow, Deepali Vasoya, Xin He, J. Tulloch, Declan King, David A. Hume, Clare Pridans, O. Dando, Tara L Spires-Jones, Giles E. Hardingham
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引用次数: 0

摘要

有证据表明小胶质细胞在阿尔茨海默病(AD)风险中的作用,尽管它们在病理级联中的位置还不完全清楚,这促使我们建立了一个缺乏小胶质细胞的ß-淀粉样蛋白病模型。我们发现有证据表明,小胶质细胞能促进斑块形成,并在斑块核心周围形成富含ß纤维的区域。然而,在缺乏小胶质细胞的情况下,仍可观察到斑块近端反应性星形胶质细胞增多、突触丧失和神经元萎缩。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Microglia determine ß-amyloid plaque burden but are non-essential for downstream pathology
Evidence points to a role for microglia in Alzheimer’s disease (AD) risk, although their position in the pathological cascade is incompletely understood, prompting us to generate a model of ß-amyloidopathy lacking microglia. We find evidence that microglia promote plaque formation and creation of an Aß fibril-rich zone surrounding the plaque core. However, plaque-proximal reactive astrogliosis, synapse loss, and neurite dystrophy are still observed in the absence of microglia.
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