整合病原体和宿主来源的血液生物标记物以加强结核病诊断:全面综述

Zhaodong Li, Yunlong Hu, Wenfei Wang, Fa Zou, Jing Yang, Wei Gao, SiWan Feng, Guanghuan Chen, Chenyan Shi, Yi Cai, Guofang Deng, Xinchun Chen
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引用次数: 0

摘要

本综述探讨了血液生物标记物在结核病(TB)诊断中不断发展的前景,重点关注来自病原体和宿主的生物标记物。这些生物标记物提供了重要的见解,可以提高诊断的准确性和及时性,这对有效管理结核病至关重要。本文件重点介绍了分子技术的最新进展,这些技术提高了对特定生物标志物的检测和定性。文件还讨论了将这些生物标记物纳入临床实践的问题,强调了这些标记物通过更精确地检测和监测疾病进展而彻底改变结核病诊断的潜力。报告还探讨了生物标志物表达的变异性和标准化验证过程的必要性等挑战,以确保在不同人群和环境中的可靠性。综述呼吁开展进一步研究,以完善这些生物标记物并充分利用其在抗击结核病方面的潜力,同时建议采用多学科方法来克服现有障碍并优化诊断策略。这项全面的分析强调了血液生物标志物作为宝贵工具在全球控制和消除结核病工作中的重要意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Integrating pathogen- and host-derived blood biomarkers for enhanced tuberculosis diagnosis: a comprehensive review
This review explores the evolving landscape of blood biomarkers in the diagnosis of tuberculosis (TB), focusing on biomarkers derived both from the pathogen and the host. These biomarkers provide critical insights that can improve diagnostic accuracy and timeliness, essential for effective TB management. The document highlights recent advancements in molecular techniques that have enhanced the detection and characterization of specific biomarkers. It also discusses the integration of these biomarkers into clinical practice, emphasizing their potential to revolutionize TB diagnostics by enabling more precise detection and monitoring of the disease progression. Challenges such as variability in biomarker expression and the need for standardized validation processes are addressed to ensure reliability across different populations and settings. The review calls for further research to refine these biomarkers and fully harness their potential in the fight against TB, suggesting a multidisciplinary approach to overcome existing barriers and optimize diagnostic strategies. This comprehensive analysis underscores the significance of blood biomarkers as invaluable tools in the global effort to control and eliminate TB.
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