痛觉神经元在过敏性鼻炎中的作用

Jianchao Cong, Hao Lv, Yu Xu
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摘要

过敏性鼻炎(AR)是一种影响鼻粘膜的慢性非感染性疾病,主要由 IgE 介导。最新研究表明,过敏性鼻炎不仅与第二类免疫密切相关,还与神经免疫密切相关。痛觉神经元是初级感觉神经元的一个亚群,在检测外部痛觉刺激和调节免疫反应方面起着关键作用。这篇综述探讨了痛觉神经元受体,并阐明了这些神经元释放的神经肽如何影响免疫系统。此外,我们还总结了免疫细胞和炎症介质对痛觉神经元的作用。全面了解痛觉神经元与免疫系统之间的动态相互作用,有助于加深我们对 AR 的神经免疫机制的理解,从而为 AR 的治疗方法开辟新的途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The role of nociceptive neurons in allergic rhinitis
Allergic rhinitis (AR) is a chronic, non-infectious condition affecting the nasal mucosa, primarily mediated mainly by IgE. Recent studies reveal that AR is intricately associated not only with type 2 immunity but also with neuroimmunity. Nociceptive neurons, a subset of primary sensory neurons, are pivotal in detecting external nociceptive stimuli and modulating immune responses. This review examines nociceptive neuron receptors and elucidates how neuropeptides released by these neurons impact the immune system. Additionally, we summarize the role of immune cells and inflammatory mediators on nociceptive neurons. A comprehensive understanding of the dynamic interplay between nociceptive neurons and the immune system augments our understanding of the neuroimmune mechanisms underlying AR, thereby opening novel avenues for AR treatment modalities.
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