深入了解线粒体靶向：作为抗癌剂的 AUTAC 双胍

Molecules Pub Date : 2024-08-09 DOI:10.3390/molecules29163773

Julie Vatté, V. Bourdeau, Gerardo Ferbeyre, A. Schmitzer

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摘要

AUTAC-Biguanide 是一种混合化合物，旨在靶向线粒体，通过有丝分裂诱导线粒体降解。这项研究揭示了双胍类药物作为癌细胞靶向药物的潜力，强调了 AUTAC-Biguanide 比二甲双胍更优越的抗增殖特性及其对癌细胞的选择性。这种增强效果背后的机制包括 AUTAC-双胍引发有丝分裂的能力。通过对这些发现进行全面分析，本研究为线粒体靶向抗癌药物领域增添了宝贵的见解。

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Gaining Insight into Mitochondrial Targeting: AUTAC-Biguanide as an Anticancer Agent

AUTAC-Biguanide is a hybrid compound designed to target mitochondria, inducing their degradation by mitophagy. This study unveils the potential of biguanides as cancer cell-targeting agents, emphasizing AUTAC-Biguanide’s superior antiproliferative properties compared to metformin and its selectivity for cancer cells. The mechanism behind this heightened effect includes the ability of AUTAC-Biguanide to trigger mitophagy. By providing a comprehensive analysis of these findings, this study adds valuable insights to the field of mitochondrial-targeting anticancer agents.

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Molecules

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