{"title":"应对全球肥胖流行病:研究维生素 D 在代谢综合征管理中的作用和内在机制","authors":"Zihui Liang, Ziliang Wang, Xueyong Liu, Yu He","doi":"10.3389/fnut.2024.1416344","DOIUrl":null,"url":null,"abstract":"The escalating prevalence of MetS, driven by global obesity trends, underscores the urgent need for innovative therapeutic strategies. To gain a deeper understanding of the therapeutic potential of vitamin D in addressing MetS, we embarked on a targeted literature review that thoroughly examines the scientific underpinnings and pivotal discoveries derived from pertinent studies, aiming to unravel the intricate mechanisms through which vitamin D exerts its effects on MetS and its components. This article explores the multifunctional role of vitamin D in the management of MetS, focusing on its regulatory effects on insulin sensitivity, lipid metabolism, inflammation, and immune response. Through an extensive review of current research, we unveil the complex mechanisms by which vitamin D influences MetS components, highlighting its potential as a therapeutic agent. Our analysis reveals that vitamin D's efficacy extends beyond bone health to include significant impacts on cellular and molecular pathways critical to MetS. We advocate for further research to optimize vitamin D supplementation as a component of precision medicine for MetS, considering the safety concerns related to dosage and long-term use.","PeriodicalId":505031,"journal":{"name":"Frontiers in Nutrition","volume":"81 11","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Confronting the global obesity epidemic: investigating the role and underlying mechanisms of vitamin D in metabolic syndrome management\",\"authors\":\"Zihui Liang, Ziliang Wang, Xueyong Liu, Yu He\",\"doi\":\"10.3389/fnut.2024.1416344\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The escalating prevalence of MetS, driven by global obesity trends, underscores the urgent need for innovative therapeutic strategies. To gain a deeper understanding of the therapeutic potential of vitamin D in addressing MetS, we embarked on a targeted literature review that thoroughly examines the scientific underpinnings and pivotal discoveries derived from pertinent studies, aiming to unravel the intricate mechanisms through which vitamin D exerts its effects on MetS and its components. This article explores the multifunctional role of vitamin D in the management of MetS, focusing on its regulatory effects on insulin sensitivity, lipid metabolism, inflammation, and immune response. Through an extensive review of current research, we unveil the complex mechanisms by which vitamin D influences MetS components, highlighting its potential as a therapeutic agent. Our analysis reveals that vitamin D's efficacy extends beyond bone health to include significant impacts on cellular and molecular pathways critical to MetS. We advocate for further research to optimize vitamin D supplementation as a component of precision medicine for MetS, considering the safety concerns related to dosage and long-term use.\",\"PeriodicalId\":505031,\"journal\":{\"name\":\"Frontiers in Nutrition\",\"volume\":\"81 11\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-08-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Frontiers in Nutrition\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3389/fnut.2024.1416344\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Nutrition","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3389/fnut.2024.1416344","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
在全球肥胖趋势的推动下,MetS 的发病率不断攀升,这凸显了对创新治疗策略的迫切需求。为了更深入地了解维生素 D 在应对 MetS 方面的治疗潜力,我们开展了一项有针对性的文献综述,深入研究了相关研究的科学基础和关键发现,旨在揭示维生素 D 对 MetS 及其组成部分产生影响的复杂机制。本文探讨了维生素 D 在 MetS 管理中的多功能作用,重点关注其对胰岛素敏感性、脂代谢、炎症和免疫反应的调节作用。通过对当前研究的广泛综述,我们揭示了维生素 D 影响 MetS 成分的复杂机制,并强调了其作为治疗剂的潜力。我们的分析表明,维生素 D 的功效不仅限于骨骼健康,还包括对 MetS 至关重要的细胞和分子通路的重大影响。考虑到与剂量和长期使用相关的安全问题,我们主张开展进一步研究,以优化维生素 D 的补充,将其作为 MetS 精准医疗的一个组成部分。
Confronting the global obesity epidemic: investigating the role and underlying mechanisms of vitamin D in metabolic syndrome management
The escalating prevalence of MetS, driven by global obesity trends, underscores the urgent need for innovative therapeutic strategies. To gain a deeper understanding of the therapeutic potential of vitamin D in addressing MetS, we embarked on a targeted literature review that thoroughly examines the scientific underpinnings and pivotal discoveries derived from pertinent studies, aiming to unravel the intricate mechanisms through which vitamin D exerts its effects on MetS and its components. This article explores the multifunctional role of vitamin D in the management of MetS, focusing on its regulatory effects on insulin sensitivity, lipid metabolism, inflammation, and immune response. Through an extensive review of current research, we unveil the complex mechanisms by which vitamin D influences MetS components, highlighting its potential as a therapeutic agent. Our analysis reveals that vitamin D's efficacy extends beyond bone health to include significant impacts on cellular and molecular pathways critical to MetS. We advocate for further research to optimize vitamin D supplementation as a component of precision medicine for MetS, considering the safety concerns related to dosage and long-term use.