{"title":"通过双曲嵌入与 Dodonaphy 的可微分系统学","authors":"Matthew Macaulay, Mathieu Fourment","doi":"10.1093/bioadv/vbae082","DOIUrl":null,"url":null,"abstract":"<p><strong>Motivation: </strong>Navigating the high dimensional space of discrete trees for phylogenetics presents a challenging problem for tree optimization. To address this, hyperbolic embeddings of trees offer a promising approach to encoding trees efficiently in continuous spaces. However, they require a differentiable tree decoder to optimize the phylogenetic likelihood. We present soft-NJ, a differentiable version of neighbour joining that enables gradient-based optimization over the space of trees.</p><p><strong>Results: </strong>We illustrate the potential for differentiable optimization over tree space for maximum likelihood inference. We then perform variational Bayesian phylogenetics by optimizing embedding distributions in hyperbolic space. We compare the performance of this approximation technique on eight benchmark datasets to state-of-the-art methods. Results indicate that, while this technique is not immune from local optima, it opens a plethora of powerful and parametrically efficient approach to phylogenetics <i>via</i> tree embeddings.</p><p><strong>Availability and implementation: </strong>Dodonaphy is freely available on the web at https://www.github.com/mattapow/dodonaphy. It includes an implementation of soft-NJ.</p>","PeriodicalId":72368,"journal":{"name":"Bioinformatics advances","volume":null,"pages":null},"PeriodicalIF":2.4000,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11310108/pdf/","citationCount":"0","resultStr":"{\"title\":\"Differentiable phylogenetics <i>via</i> hyperbolic embeddings with Dodonaphy.\",\"authors\":\"Matthew Macaulay, Mathieu Fourment\",\"doi\":\"10.1093/bioadv/vbae082\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Motivation: </strong>Navigating the high dimensional space of discrete trees for phylogenetics presents a challenging problem for tree optimization. To address this, hyperbolic embeddings of trees offer a promising approach to encoding trees efficiently in continuous spaces. However, they require a differentiable tree decoder to optimize the phylogenetic likelihood. We present soft-NJ, a differentiable version of neighbour joining that enables gradient-based optimization over the space of trees.</p><p><strong>Results: </strong>We illustrate the potential for differentiable optimization over tree space for maximum likelihood inference. We then perform variational Bayesian phylogenetics by optimizing embedding distributions in hyperbolic space. We compare the performance of this approximation technique on eight benchmark datasets to state-of-the-art methods. Results indicate that, while this technique is not immune from local optima, it opens a plethora of powerful and parametrically efficient approach to phylogenetics <i>via</i> tree embeddings.</p><p><strong>Availability and implementation: </strong>Dodonaphy is freely available on the web at https://www.github.com/mattapow/dodonaphy. It includes an implementation of soft-NJ.</p>\",\"PeriodicalId\":72368,\"journal\":{\"name\":\"Bioinformatics advances\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.4000,\"publicationDate\":\"2024-06-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11310108/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Bioinformatics advances\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1093/bioadv/vbae082\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"MATHEMATICAL & COMPUTATIONAL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bioinformatics advances","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1093/bioadv/vbae082","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"MATHEMATICAL & COMPUTATIONAL BIOLOGY","Score":null,"Total":0}
Differentiable phylogenetics via hyperbolic embeddings with Dodonaphy.
Motivation: Navigating the high dimensional space of discrete trees for phylogenetics presents a challenging problem for tree optimization. To address this, hyperbolic embeddings of trees offer a promising approach to encoding trees efficiently in continuous spaces. However, they require a differentiable tree decoder to optimize the phylogenetic likelihood. We present soft-NJ, a differentiable version of neighbour joining that enables gradient-based optimization over the space of trees.
Results: We illustrate the potential for differentiable optimization over tree space for maximum likelihood inference. We then perform variational Bayesian phylogenetics by optimizing embedding distributions in hyperbolic space. We compare the performance of this approximation technique on eight benchmark datasets to state-of-the-art methods. Results indicate that, while this technique is not immune from local optima, it opens a plethora of powerful and parametrically efficient approach to phylogenetics via tree embeddings.
Availability and implementation: Dodonaphy is freely available on the web at https://www.github.com/mattapow/dodonaphy. It includes an implementation of soft-NJ.