突尼斯 1 型糖尿病儿童向胰岛素类似物过渡:疗效与安全性

Q3 Medicine
Asma Marzouk, Mariem Lajili, Ilyes Ben Yahya, Rahma Thebti, Saad Ayeb, Asma Bouaziz
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引用次数: 0

摘要

导言:目前缺乏对从人胰岛素转为胰岛素类似物治疗的影响进行评估的研究,尤其是在低收入和中等收入国家的儿科人群中。目的:本研究旨在回顾性评估突尼斯儿童糖尿病患者从人胰岛素转为胰岛素类似物治疗的有效性和安全性:这项回顾性描述性研究包括使用人胰岛素治疗至少一年后改变胰岛素治疗方案的 1 型糖尿病患儿。在从人胰岛素(NPH + 速效胰岛素)过渡到基础胰岛素类似物方案后,对临床、治疗和血糖平衡参数进行了评估:这项研究包括 60 名患者。转换后,所有患者的平均空腹血糖水平均显著下降(11.11 mmol/l vs. 8.62 mmol/l;p=0.024)。坚持饮食(从 9.93% 降至 8.38%;p=0.06)和/或定期参加体育锻炼(从 10.40% 降至 8.61%;p=0.043)的儿童糖化血红蛋白 A1C 水平明显下降。每年发生低血糖的平均次数从 4.03 次/年降至 2.36 次/年(p=0.006),同时因酸-酮症失代偿住院的患者比例也有所下降(从 27% 降至 10%;p=0.001)。由于经济拮据,82%的患者每天重复使用微量细针≥2次,12%的患者因无法获得自费微量细针或社会保险中断而被迫恢复最初的胰岛素治疗方案:尽管胰岛素类似物具有明显的优势,但作为中低收入国家儿童糖尿病患者的治疗选择,胰岛素类似物的使用仍面临挑战。这些挑战阻碍了最佳血糖控制目标的实现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Transitioning to Insulin Analogs in Tunisian Children with Type 1 Diabetes: Efficacy and Safety.

Introduction: there is a lack of research evaluating the impact of therapeutic switching from human insulin to analogues, particularly in paediatric populations from low- and middle-income countries.

Aim: The study aimed to retrospectively assess the effectiveness and safety of transitioning from human insulin to insulin analogs in Tunisian children with diabetes.

Methods: This retrospective descriptive study included children with type 1 diabetes who changed their insulin therapy protocol after at least one year of treatment with human insulin. Clinical, therapeutic, and glycaemic homeostasis parameters were assessed following the transition from human insulin (NPH + rapid-acting insulin) to the Basal-Bolus insulin analog- protocol.

Results: The study included 60 patients. Following the switch, all patients showed a significant reduction in mean fasting blood glucose levels (11.11 mmol/l vs. 8.62 mmol/l; p=0.024). Glycated haemoglobin A1C levels decreased notably in children who adhered to their diet (from 9.93% to 8.38%; p=0.06) and/or engaged in regular physical activity (from 10.40% to 8.61%; p=0.043). The average number of hypoglycemic events per year decreased from 4.03 events/year to 2.36 events/year (p=0.006), along with a decrease in the rate of patients hospitalized for acid-ketotic decompensation (from 27% to 10%; p=0.001). Financial constraints led to 82% of patients reusing microfine needles ≥2 times per day, and 12% were compelled to revert to the initial insulin therapy protocol due to a lack of access to self-financed microfine needles or discontinued social coverage.

Conclusions: Although insulin analogues offer clear benefits, their use poses challenges as a therapeutic choice for children with diabetes in low- to middle-income countries. These challenges hinder the achievement of optimal glycemic control goals.

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来源期刊
Tunisie Medicale
Tunisie Medicale Medicine-Medicine (all)
CiteScore
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72
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