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引用次数: 0
摘要
非酒精性脂肪肝(NAFLD)是最常见的慢性肝病,已成为全球主要的健康问题。本综述总结了治疗非酒精性脂肪肝的方法和机制,包括地中海饮食、体力活动和锻炼、减肥手术和特定的治疗药物,包括他汀类药物、过氧化物酶体增殖物激活受体激动剂、西尼罗和法尼类固醇 X 受体激动剂。生物活性物质,如肽、生物碱、多酚化合物、水飞蓟素、抗生素、脂肪酸、维生素、益生菌、合成益生菌和羊齿植物等,也具有防治非酒精性脂肪肝的作用。考虑到它们不同的作用机制,将其中一些结合起来可能会被证明是治疗非酒精性脂肪肝的有效方法。有鉴于此,本综述介绍了治疗非酒精性脂肪肝的最新进展和未来前景。
Current strategies for nonalcoholic fatty liver disease treatment (Review).
Nonalcoholic fatty liver disease (NAFLD), the most common chronic hepatic disease, has become a leading health problem worldwide. The present review summarized the methods and mechanisms to treat NAFLD, including the Mediterranean diet, physical activity and exercise, bariatric surgery and specific therapeutic agents, including statins, peroxisome proliferator‑activated receptor agonists, cenicriviroc and farnesoid X receptor agonists. Biologically active substances, such as peptides, alkaloids, polyphenolic compounds, silymarin, antibiotics, fatty acids, vitamins, probiotics, synbiotics and lamiaceae have also demonstrated actions that combat NAFLD. Considering their different mechanisms of action, combining some of them may prove an efficacious treatment for NAFLD. In this light, the present review describes recent progress and future prospects in treating NAFLD.
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