Raghad Alhajaji, Mayada Mohammad Samkari, Mona A Althobaiti, Bashaer Ruddah Al-Ahmadi, Alaa Mohammed Bugis, Amjad Mohammed Bugis, Fatimah Yaseen Sabbagh, Somaya A Althobaiti, Amro S Bukari, Safenaz Meshal Alqurashi, Hana Abdullah Mshrai, Omar Ahmed Abdelwahab
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引用次数: 0
摘要
背景：自发性细菌性腹膜炎（SBP自发性细菌性腹膜炎（SBP）是肝硬化患者常见的一种严重且可能致命的疾病。本荟萃分析旨在评估糖尿病（DM）作为肝硬化患者SBP风险因素的情况：按照PRISMA指南，共纳入15项研究，共计76815名患者。采用纽卡斯尔-渥太华量表（NOS）评估了偏倚风险。我们使用RevMan软件将结果显示为风险比（RR）及相应的95%置信区间（CI）。此外，我们还汇总了纳入研究的 DM 患者发生 SBP 的危险比 (HR)：荟萃分析表明，肝硬化DM患者罹患SBP的风险显著增加（HR：1.26；95% CI [1.05-1.51]，P=.01；HR：1.70；95% CI [1.32-2.18]，PC结论：该研究表明，DM 是导致 SBP 的一个独立风险因素，强调了在这一特殊人群中采取有针对性的预防措施的必要性。
Diabetes mellitus and the risk of spontaneous bacterial peritonitis in patients with liver cirrhosis: a systematic review and meta-analysis.
Background: Spontaneous bacterial peritonitis (SBP) represents a critical and potentially lethal condition that typically develops in individuals with liver cirrhosis. This meta-analysis aimed to assess diabetes mellitus (DM) as a risk factor for SBP in liver cirrhotic patients.
Methods: Following PRISMA guidelines, fifteen studies were included, for a total of 76 815 patients. The risk of bias was assessed using the Newcastle-Ottawa scale (NOS). We represented the results as risk ratios (RR) with the corresponding 95% confidence intervals (CI) using RevMan software. Additionally, we pooled the hazard ratios (HR) for developing SBP in patients with DM from the included studies.
Results: The meta-analysis shows a significantly increased risk of SBP in cirrhotic patients with DM (HR: 1.26; 95% CI [1.05-1.51], P=.01; HR: 1.70; 95% CI [1.32-2.18], P<.001).
Conclusions: The study signifies that DM is an independent risk factor for SBP, emphasizing the need for targeted preventive measures in this specific population.
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