铁营养对新生猪肠道发育和免疫细胞分化的影响

IF 6.3 Q1 AGRICULTURE, DAIRY & ANIMAL SCIENCE
Yao Liu, Aimin Wu, Bing Yu, Jun He, Jie Yu, Xiangbing Mao, Ping Zheng, Yuheng Luo, Junqiu Luo, Junning Pu, Hui Yan, Daiwen Chen
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引用次数: 0

摘要

背景:适当补铁对新生儿的生长发育至关重要。然而,有关铁过量对新生儿生长和免疫平衡影响的报道很少。因此,本研究旨在通过给新生猪注射不同水平的铁,研究铁营养对新生儿生长和肠道免疫的影响:结果:我们发现,缺铁和铁过量都会导致新生猪生长缓慢。缺铁和铁超载导致空肠肠屏障和抗氧化标记基因下调,并促进猪空肠和肠系膜淋巴结(MLN)CD8+ T 细胞分化,破坏肠道健康。此外,铁水平改变了血清铁和组织铁的状态,导致氧化还原状态紊乱,影响宿主的先天性免疫和适应性免疫:这些发现强调了铁营养对宿主健康的影响,阐明了铁在调节氧化还原状态和免疫发展中的重要性。这项研究为了解生命早期铁代谢对氧化还原状态和免疫功能的调控提供了宝贵的见解,从而有助于制定有针对性的干预措施和营养策略,优化新生儿的铁营养。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The influence of iron nutrition on the development of intestine and immune cell divergency in neonatal pigs.

Background: Appropriate iron supplementation is essential for neonatal growth and development. However, there are few reports on the effects of iron overload on neonatal growth and immune homeostasis. Thus, the aim of this study was to investigate the effects of iron nutrition on neonatal growth and intestinal immunity by administering different levels of iron to neonatal pigs.

Results: We found that iron deficiency and iron overload resulted in slow growth in neonatal pigs. Iron deficiency and iron overload led to down-regulation of jejunum intestinal barrier and antioxidant marker genes, and promoted CD8+ T cell differentiation in jejunum and mesenteric lymph nodes (MLN) of pigs, disrupting intestinal health. Moreover, iron levels altered serum iron and tissue iron status leading to disturbances in redox state, affecting host innate and adaptive immunity.

Conclusions: These findings emphasized the effect of iron nutrition on host health and elucidated the importance of iron in regulating redox state and immunity development. This study provided valuable insights into the regulation of redox state and immune function by iron metabolism in early life, thus contributing to the development of targeted interventions and nutritional strategies to optimize iron nutrition in neonates.

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