乳腺癌中 SUMOylation 与其他翻译后修饰之间的相互影响。

IF 9.2 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Bajin Wei, Fan Yang, Luyang Yu, Cong Qiu
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引用次数: 0

摘要

乳腺癌是发病率最高的肿瘤类型,也是全球妇女死亡的首要原因。乳腺癌肿瘤发生和发展的复杂病理生理过程受蛋白质翻译后修饰(PTMs)的调控,PTMs 由不同的致癌因子和信号通路触发,其中小泛素样修饰物(SUMOylation)在这方面的作用尤为关键。最近的研究表明,SUMOylation 并非单独起作用,而是与磷酸化、泛素化、乙酰化和甲基化等其他 PTM 相互作用,从而调节乳腺癌的各种病理活动。本综述探讨了 SUMOylation 与其他 PTMs 之间新的和现有的串扰机制。通常情况下,SUMOylation 受磷酸化调控以发挥反馈控制作用,同时也会调节后续的泛素化、乙酰化或甲基化。促进或抑制乳腺癌的串扰对是蛋白质特异性和位点特异性的。在机制上,氨基酸侧链电荷、蛋白质构象或特定结构域或位点上特定位点的改变是复杂串扰的基础。总之,这篇综述的中心是阐明 SUMOylation 与其他 PTMs 在乳腺癌致癌和进展过程中的相互影响,并讨论导致这些相互作用的分子机制,为它们在促进乳腺癌新疗法方面的潜在应用提供见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Crosstalk between SUMOylation and other post-translational modifications in breast cancer.

Breast cancer represents the most prevalent tumor type and a foremost cause of mortality among women globally. The complex pathophysiological processes of breast cancer tumorigenesis and progression are regulated by protein post-translational modifications (PTMs), which are triggered by different carcinogenic factors and signaling pathways, with small ubiquitin-like modifier (SUMOylation) emerging as a particularly pivotal player in this context. Recent studies have demonstrated that SUMOylation does not act alone, but interacts with other PTMs, such as phosphorylation, ubiquitination, acetylation, and methylation, thereby leading to the regulation of various pathological activities in breast cancer. This review explores novel and existing mechanisms of crosstalk between SUMOylation and other PTMs. Typically, SUMOylation is regulated by phosphorylation to exert feedback control, while also modulates subsequent ubiquitination, acetylation, or methylation. The crosstalk pairs in promoting or inhibiting breast cancer are protein-specific and site-specific. In mechanism, alterations in amino acid side chain charges, protein conformations, or the occupation of specific sites at specific domains or sites underlie the complex crosstalk. In summary, this review centers on elucidating the crosstalk between SUMOylation and other PTMs in breast cancer oncogenesis and progression and discuss the molecular mechanisms contributing to these interactions, offering insights into their potential applications in facilitating novel treatments for breast cancer.

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来源期刊
Cellular & Molecular Biology Letters
Cellular & Molecular Biology Letters 生物-生化与分子生物学
CiteScore
11.60
自引率
13.30%
发文量
101
审稿时长
3 months
期刊介绍: Cellular & Molecular Biology Letters is an international journal dedicated to the dissemination of fundamental knowledge in all areas of cellular and molecular biology, cancer cell biology, and certain aspects of biochemistry, biophysics and biotechnology.
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