从实验室到立法：学术研究与政治现实之间的相互作用。

IF 2.7 4区生物学 Q2 BIOCHEMICAL RESEARCH METHODS

SLAS Discovery Pub Date : 2024-08-08 DOI:10.1016/j.slasd.2024.100175

Saumya Gopalkrishnan Ph.D

引用次数: 0

摘要

大流行病对社会造成了巨大的人员和经济损失。考虑到我们全球社会的相互关联性，再次发生病毒性大流行似乎几乎不可避免。2021 年，在 COVID-19 大流行之后，拜登政府采取了多方面的措施来遏制疾病的传播，包括分发疫苗、发布公共卫生指南、检测和追踪、提供经济救济以及投资研发。为此，从《美国救援计划法案》1 中拨款 32 亿美元，启动了由卫生与公众服务部（HHS）负责的大流行病抗病毒计划（APP）2。该计划的核心是建立九个抗病毒药物研发中心（AViDD）3 ，由美国国家过敏与传染病研究所（NIAID）负责监督，承担发现和开发新型直接作用抗病毒疗法的五年综合任务。这些努力不仅旨在缓解病毒爆发升级为全面流行的情况，还旨在为患者提供有效的治疗。12 亿美元被指定用于 AViDD 计划。随后，5.77 亿美元用于维持 AViDD 中心最初三年的运作。随着前三年的资助将于 2025 财年结束，各中心的许多项目在确定有希望的先导化合物方面取得了重大进展，这些化合物已证明对冠状病毒和其他具有流行潜力的病毒有效。9 个中心发表了约 150 篇公开出版物，一些中心还拥有有前景化合物的专利（临时专利或其他专利）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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From labs to legislation: The interplay between academic research and political realities

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来源期刊

SLAS Discovery Chemistry-Analytical Chemistry

CiteScore

7.00

自引率

3.20%

发文量

审稿时长

39 days

期刊介绍： Advancing Life Sciences R&D: SLAS Discovery reports how scientists develop and utilize novel technologies and/or approaches to provide and characterize chemical and biological tools to understand and treat human disease. SLAS Discovery is a peer-reviewed journal that publishes scientific reports that enable and improve target validation, evaluate current drug discovery technologies, provide novel research tools, and incorporate research approaches that enhance depth of knowledge and drug discovery success. SLAS Discovery emphasizes scientific and technical advances in target identification/validation (including chemical probes, RNA silencing, gene editing technologies); biomarker discovery; assay development; virtual, medium- or high-throughput screening (biochemical and biological, biophysical, phenotypic, toxicological, ADME); lead generation/optimization; chemical biology; and informatics (data analysis, image analysis, statistics, bio- and chemo-informatics). Review articles on target biology, new paradigms in drug discovery and advances in drug discovery technologies. SLAS Discovery is of particular interest to those involved in analytical chemistry, applied microbiology, automation, biochemistry, bioengineering, biomedical optics, biotechnology, bioinformatics, cell biology, DNA science and technology, genetics, information technology, medicinal chemistry, molecular biology, natural products chemistry, organic chemistry, pharmacology, spectroscopy, and toxicology. SLAS Discovery is a member of the Committee on Publication Ethics (COPE) and was published previously (1996-2016) as the Journal of Biomolecular Screening (JBS).