{"title":"日本的颗粒物与慢性肾病发病率：茨城县健康研究》（IPHS）。","authors":"Kei Nagai, Shin Araki, Toshimi Sairenchi, Kayo Ueda, Kazumasa Yamagishi, Masayuki Shima, Kouhei Yamamoto, Hiroyasu Iso, Fujiko Irie","doi":"10.31662/jmaj.2024-0032","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Global health hazards caused by air pollution, such as chronic kidney disease (CKD), have been gaining attention; however, air pollution-associated CKD has not been explored in Japan.</p><p><strong>Methods: </strong>We examined 77,770 men and women with estimated glomerular filtration rate (eGFR) ≥60 ml/min/1.73 m<sup>2</sup> in the Ibaraki Prefecture who participated in annual community-based health checkups from 1993 at 40-75 years old and were followed up through December 2020. The outcome was newly developed kidney dysfunction with eGFR of <60 ml/min/1.73 m<sup>2</sup> during follow-up. To assess air pollution, a PM<sub>2.5</sub> exposure model was employed to estimate yearly means at 1 × 1-km resolution, converted into means at the municipal level. Hazard modeling was employed to examine PM<sub>2.5</sub> concentrations in residential areas as a risk factor for outcomes.</p><p><strong>Results: </strong>Participants were distributed across 23 municipalities in the Ibaraki Prefecture, with PM<sub>2.5</sub> concentrations between 16.2 and 33.4 μg/m<sup>3</sup> (mean, 22.7 μg/m<sup>3</sup>) in 1987-1995 as the exposure period. There were 942 newly developed kidney dysfunctions during follow-up. Based on 1987-1995 PM<sub>2.5</sub> concentrations as the baseline exposure, the multivariate-adjusted hazard ratio per 10-μg/m<sup>3</sup> increase in PM<sub>2.5</sub> for newly developed kidney dysfunction was 1.02 (95%CI, 0.80-1.24) in men and 1.19 (95%CI, 0.95-1.44) in women.</p><p><strong>Conclusions: </strong>Elevated PM<sub>2.5</sub> did not represent a significant risk factor for incident CKD in a prefecture in Japan.</p>","PeriodicalId":73550,"journal":{"name":"JMA journal","volume":null,"pages":null},"PeriodicalIF":1.5000,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11301005/pdf/","citationCount":"0","resultStr":"{\"title\":\"Particulate Matter and Incident Chronic Kidney Disease in Japan: The Ibaraki Prefectural Health Study (IPHS).\",\"authors\":\"Kei Nagai, Shin Araki, Toshimi Sairenchi, Kayo Ueda, Kazumasa Yamagishi, Masayuki Shima, Kouhei Yamamoto, Hiroyasu Iso, Fujiko Irie\",\"doi\":\"10.31662/jmaj.2024-0032\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Global health hazards caused by air pollution, such as chronic kidney disease (CKD), have been gaining attention; however, air pollution-associated CKD has not been explored in Japan.</p><p><strong>Methods: </strong>We examined 77,770 men and women with estimated glomerular filtration rate (eGFR) ≥60 ml/min/1.73 m<sup>2</sup> in the Ibaraki Prefecture who participated in annual community-based health checkups from 1993 at 40-75 years old and were followed up through December 2020. The outcome was newly developed kidney dysfunction with eGFR of <60 ml/min/1.73 m<sup>2</sup> during follow-up. To assess air pollution, a PM<sub>2.5</sub> exposure model was employed to estimate yearly means at 1 × 1-km resolution, converted into means at the municipal level. Hazard modeling was employed to examine PM<sub>2.5</sub> concentrations in residential areas as a risk factor for outcomes.</p><p><strong>Results: </strong>Participants were distributed across 23 municipalities in the Ibaraki Prefecture, with PM<sub>2.5</sub> concentrations between 16.2 and 33.4 μg/m<sup>3</sup> (mean, 22.7 μg/m<sup>3</sup>) in 1987-1995 as the exposure period. There were 942 newly developed kidney dysfunctions during follow-up. Based on 1987-1995 PM<sub>2.5</sub> concentrations as the baseline exposure, the multivariate-adjusted hazard ratio per 10-μg/m<sup>3</sup> increase in PM<sub>2.5</sub> for newly developed kidney dysfunction was 1.02 (95%CI, 0.80-1.24) in men and 1.19 (95%CI, 0.95-1.44) in women.</p><p><strong>Conclusions: </strong>Elevated PM<sub>2.5</sub> did not represent a significant risk factor for incident CKD in a prefecture in Japan.</p>\",\"PeriodicalId\":73550,\"journal\":{\"name\":\"JMA journal\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.5000,\"publicationDate\":\"2024-07-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11301005/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"JMA journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.31662/jmaj.2024-0032\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/6/3 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"JMA journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.31662/jmaj.2024-0032","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/6/3 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
Particulate Matter and Incident Chronic Kidney Disease in Japan: The Ibaraki Prefectural Health Study (IPHS).
Introduction: Global health hazards caused by air pollution, such as chronic kidney disease (CKD), have been gaining attention; however, air pollution-associated CKD has not been explored in Japan.
Methods: We examined 77,770 men and women with estimated glomerular filtration rate (eGFR) ≥60 ml/min/1.73 m2 in the Ibaraki Prefecture who participated in annual community-based health checkups from 1993 at 40-75 years old and were followed up through December 2020. The outcome was newly developed kidney dysfunction with eGFR of <60 ml/min/1.73 m2 during follow-up. To assess air pollution, a PM2.5 exposure model was employed to estimate yearly means at 1 × 1-km resolution, converted into means at the municipal level. Hazard modeling was employed to examine PM2.5 concentrations in residential areas as a risk factor for outcomes.
Results: Participants were distributed across 23 municipalities in the Ibaraki Prefecture, with PM2.5 concentrations between 16.2 and 33.4 μg/m3 (mean, 22.7 μg/m3) in 1987-1995 as the exposure period. There were 942 newly developed kidney dysfunctions during follow-up. Based on 1987-1995 PM2.5 concentrations as the baseline exposure, the multivariate-adjusted hazard ratio per 10-μg/m3 increase in PM2.5 for newly developed kidney dysfunction was 1.02 (95%CI, 0.80-1.24) in men and 1.19 (95%CI, 0.95-1.44) in women.
Conclusions: Elevated PM2.5 did not represent a significant risk factor for incident CKD in a prefecture in Japan.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
