修复基因组链间交联。

IF 3 3区生物学 Q2 GENETICS & HEREDITY

DNA Repair Pub Date : 2024-07-30 DOI:10.1016/j.dnarep.2024.103739

Marina A. Bellani, Althaf Shaik, Ishani Majumdar, Chen Ling, Michael M. Seidman

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引用次数: 0

摘要

基因组链间交联（ICL）是由正常细胞代谢过程中产生的活性物种、微生物组产生的活性物种以及癌症化疗中使用的活性物种形成的。虽然有多种依赖复制和独立 ICL 修复的方法，但每种方法的关键步骤都是解除一条 DNA 链与另一条 DNA 链的连接。我们对脱钩机制的深入了解大多来自功能强大的模型系统，该系统以质粒为基础，将定义好的 ICL 导入细胞或无细胞提取物中。在这里，我们描述了外源性和内源性 ICL 形成化合物的特性，并从历史角度介绍了 ICL 修复的早期工作。我们讨论了在模型系统中阐明的脱钩模式、耐药性肿瘤中的一致或不一致，以及对 DNA 加合物（包括由代谢醛形成的 ICL）不断发展的看法。

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Repair of genomic interstrand crosslinks

Genomic interstrand crosslinks (ICLs) are formed by reactive species generated during normal cellular metabolism, produced by the microbiome, and employed in cancer chemotherapy. While there are multiple options for replication dependent and independent ICL repair, the crucial step for each is unhooking one DNA strand from the other. Much of our insight into mechanisms of unhooking comes from powerful model systems based on plasmids with defined ICLs introduced into cells or cell free extracts. Here we describe the properties of exogenous and endogenous ICL forming compounds and provide an historical perspective on early work on ICL repair. We discuss the modes of unhooking elucidated in the model systems, the concordance or lack thereof in drug resistant tumors, and the evolving view of DNA adducts, including ICLs, formed by metabolic aldehydes.

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来源期刊

DNA Repair 生物-毒理学

CiteScore

7.60

自引率

5.30%

发文量

审稿时长

59 days

期刊介绍： DNA Repair provides a forum for the comprehensive coverage of DNA repair and cellular responses to DNA damage. The journal publishes original observations on genetic, cellular, biochemical, structural and molecular aspects of DNA repair, mutagenesis, cell cycle regulation, apoptosis and other biological responses in cells exposed to genomic insult, as well as their relationship to human disease. DNA Repair publishes full-length research articles, brief reports on research, and reviews. The journal welcomes articles describing databases, methods and new technologies supporting research on DNA repair and responses to DNA damage. Letters to the Editor, hot topics and classics in DNA repair, historical reflections, book reviews and meeting reports also will be considered for publication.