通过应用显示遗漏对象的决策分析模型(DAMWOOD)提高决策模型的透明度。

IF 4.4 3区 医学 Q1 ECONOMICS
PharmacoEconomics Pub Date : 2024-11-01 Epub Date: 2024-08-07 DOI:10.1007/s40273-024-01401-y
Jeff Round, Erin Kirwin, Sasha van Katwyk, Christopher McCabe
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引用次数: 0

摘要

2019 年冠状病毒病(COVID-19)大流行提高了公众对流行病学和经济决策模型对公共决策影响的认识。与此同时,对用于公共决策的决策模型的开发、分析、报告和使用的审查也在增加。因此,为了提高决策的透明度和信任度,模型开发者必须向所有利益相关者清楚地解释和说明为支持决策而开发的模型中包含和不包含的内容。我们的目标是为改善建模者与决策者之间的沟通提供工具,从而提高决策的透明度。为此,我们将 Haber 等人(Ann Epidemiol 68:64-71,2022 年)最近描述的显示遗漏对象的有向无环图(DAGWOOD)方法扩展到决策分析模型中,给出了显示遗漏对象的决策分析模型(DAMWOOD)方法。DAMWOOD 是一个框架,用于识别决策模型中遗漏的对象,以及考虑遗漏对模型结果的影响。决策模型中遗漏的对象可分为排除对象(已知和未知混杂因素)、误导对象(替代模型路径)或结构对象(如模型类型、估计对象间关系的方法)。DAMWOOD 要求模型开发人员使用明确的声明,并提供包含和省略对象的说明,支持与模型用户和利益相关者的交流,使他们能够就模型中包含或省略哪些对象向建模人员提供意见和反馈。在开发 DAMWOOD 的过程中,我们考虑了大流行病政策应对建模过程中遇到的两个挑战。首先,决策者并不总是能充分明确地说明决策问题的范围,这就要求建模人员凭直觉来确定应考虑哪些政策方案,以及/或在评估时应考虑哪些结果。其次,很少有足够的透明度来确保利益相关者能够了解模型中包含的内容和原因。这限制了利益相关者向决策者倡导优先考虑特定结果和质疑模型结果的能力。为了说明 DAMWOOD 的应用,我们将其应用于之前发布的 COVID-19 疫苗分配优化模型。DAMWOOD 图表说明了改进模型假设沟通的方法。这些图表明确指出了哪些结果被省略,并提供了省略对模型结果的预期影响的信息。我们讨论了 DAMWOOD 在以下方面的实用性:确定决策问题的框架、传达模型结构和结果,以及与决策制定者和受决策制定影响者进行互动。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Improving Transparency of Decision Models Through the Application of Decision Analytic Models with Omitted Objects Displayed (DAMWOOD).

Improving Transparency of Decision Models Through the Application of Decision Analytic Models with Omitted Objects Displayed (DAMWOOD).

The coronavirus disease 2019 (COVID-19) pandemic has increased public awareness of the influence of epidemiological and economic decision models on public policy decisions. Alongside this is an increased scrutiny on the development, analysis, reporting and utilisation of decision models for public policy making. Therefore, it is important that model developers can clearly explain and justify to all stakeholders what is included and excluded from a model developed to support decision-making, to both improve transparency and trust in decision-making. Our aim is to provide tools for improving communication between modellers and decision-makers, leading to improved transparency in decision-making. To do so, we extend the recently described directed acyclic graphs with omitted objects displayed (DAGWOOD) approach from Haber et al. (Ann Epidemiol 68:64-71, 2022) to decision analytic models, giving the decision analytic models with omitted objects displayed (DAMWOOD) approach. DAMWOOD is a framework for the identification of objects omitted from a decision model, as well as for consideration of the effects of omissions on model outcomes. Objects omitted from a decision model are classed as either an exclusion (known and unknown confounders), misdirection (alternative model pathways) or structure (e.g. model type, methods for estimating relationships between objects). DAMWOOD requires model developers to use explicit statements and provide illustration of included and omitted objects, supporting communication with model users and stakeholders, allowing them to provide input and feedback to modellers about which objects to include or omit in a model. In developing DAMWOOD, we considered two challenges we encountered in modelling for pandemic policy response. First, the scope of the decision problem is not always made sufficiently explicit by decision-makers, requiring modellers to intuit which policy options should be considered, and/or which outcomes should be considered in their evaluation. Second, there is rarely sufficient transparency to ensure stakeholders can see what is included in models and why. This limits stakeholders' ability to advocate to decision-makers for the prioritisation of specific outcomes and challenge the model results. To illustrate the application of DAMWOOD, we apply it to a previously published COVID-19 vaccine allocation optimisation model. The DAMWOOD diagrams illustrate the ways in which it is possible to improve the communication of model assumptions. The diagrams make explicit which outcomes are omitted and provide information on the expected impact of the omissions on model results. We discuss the usefulness of DAMWOOD for framing the decision problem, communicating the model structure and results and engaging with those making and affected by the decisions the model is developed to inform.

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来源期刊
PharmacoEconomics
PharmacoEconomics 医学-药学
CiteScore
8.10
自引率
9.10%
发文量
85
审稿时长
6-12 weeks
期刊介绍: PharmacoEconomics is the benchmark journal for peer-reviewed, authoritative and practical articles on the application of pharmacoeconomics and quality-of-life assessment to optimum drug therapy and health outcomes. An invaluable source of applied pharmacoeconomic original research and educational material for the healthcare decision maker. PharmacoEconomics is dedicated to the clear communication of complex pharmacoeconomic issues related to patient care and drug utilization. PharmacoEconomics offers a range of additional features designed to increase the visibility, readership and educational value of the journal’s content. Each article is accompanied by a Key Points summary, giving a time-efficient overview of the content to a wide readership. Articles may be accompanied by plain language summaries to assist readers who have some knowledge of, but not in-depth expertise in, the area to understand the scientific content and overall implications of the article.
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