T 细胞衰老的特征和机制：癌症免疫疗法的潜在靶点

IF 4.5 3区医学 Q2 IMMUNOLOGY

European Journal of Immunology Pub Date : 2024-08-06 DOI:10.1002/eji.202451093

Han Wu, Junru Li, Zhen Zhang, Yi Zhang

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引用次数: 0

摘要

免疫衰老，即免疫系统的老化，会导致功能缺陷，尤其是 T 细胞会发生重大变化。尽管许多研究调查了健康老龄化过程中与年龄相关的 T 细胞表型，但在癌症等病理情况下，年轻人群中也观察到了衰老的 T 细胞。本综述总结了与年龄相关的 T 细胞改变和标志物、机制以及衰老 T 细胞与肿瘤微环境之间关系的最新进展。我们还讨论了针对衰老 T 细胞的潜在策略，以预防老年相关疾病并提高肿瘤免疫疗法的疗效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Characteristics and mechanisms of T-cell senescence: A potential target for cancer immunotherapy

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Characteristics and mechanisms of T-cell senescence: A potential target for cancer immunotherapy

Immunosenescence, the aging of the immune system, leads to functional deficiencies, particularly in T cells, which undergo significant changes. While numerous studies have investigated age-related T-cell phenotypes in healthy aging, senescent T cells have also been observed in younger populations during pathological conditions like cancer. This review summarizes the recent advancements in age-associated alterations and markers of T cells, mechanisms, and the relationship between senescent T cells and the tumor microenvironment. We also discuss potential strategies for targeting senescent T cells to prevent age-related diseases and enhance tumor immunotherapy efficacy.

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来源期刊

European Journal of Immunology 医学-免疫学

CiteScore

8.30

自引率

3.70%

发文量

224

审稿时长

2 months

期刊介绍： The European Journal of Immunology (EJI) is an official journal of EFIS. Established in 1971, EJI continues to serve the needs of the global immunology community covering basic, translational and clinical research, ranging from adaptive and innate immunity through to vaccines and immunotherapy, cancer, autoimmunity, allergy and more. Mechanistic insights and thought-provoking immunological findings are of interest, as are studies using the latest omics technologies. We offer fast track review for competitive situations, including recently scooped papers, format free submission, transparent and fair peer review and more as detailed in our policies.