{"title":"质子泵抑制剂的使用与牙周病和种植体周围炎严重程度的关系:系统性综述。","authors":"Amirhossein Vedaei, Yasaman Salimi, Zahra Iranshahi, Negar Sadighnia, Hamed Taheri, Mahsa Eyvani, Mobina Bagherianlemraski, Zahra Taheri, Mohammad Mahdi Khanmohammadi, Simin Bina, Arghavan Kavousi, Sara Bagheri-Hosseini, Seyed Ali Mosaddad, Nozhan Azimi, Rubina Valipour, Seyed Mahmoud Atarodi, Niloofar Deravi","doi":"10.1563/aaid-joi-D-23-00091","DOIUrl":null,"url":null,"abstract":"<p><p>This systematic review investigates the probable effect of proton pump inhibitor (PPI) use on the severity of periodontal disease and peri-implantitis and implant survival. We conducted a literature search in PubMed, Scopus, and Cochrane Central Library up to April 2024. Two review authors independently screened the title and abstracts and then the full texts of retrieved studies. Observational and clinical trial studies that assessed the association between PPI use and periodontal disease severity and peri-implantitis or implant survival were included. Data extraction from the included studies was done by 2 reviewers independently. Of 940 studies initially retrieved from online searching, 7 met the inclusion criteria. Three studies examined periodontitis, whereas 4 focused on peri-implantitis and implant longevity. On the contrary, evidence regarding the impact of PPI use on peri-implantitis and implant survival is conflicting. Therefore, more well-designed randomized controlled trials are warranted to come to a definite conclusion. Because PPIs alter the gut microbiome and affect bone, plus that the pathogenesis and etiology of periodontal disease are affected by bacteria within the periodontal pocket, it is hypothesized that they may affect periodontal pathogenesis.</p>","PeriodicalId":519890,"journal":{"name":"The Journal of oral implantology","volume":" ","pages":"659-664"},"PeriodicalIF":0.0000,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Association Between Proton Pump Inhibitor Use and the Severity of Periodontal Disease and Peri-Implantitis: A Systematic Review.\",\"authors\":\"Amirhossein Vedaei, Yasaman Salimi, Zahra Iranshahi, Negar Sadighnia, Hamed Taheri, Mahsa Eyvani, Mobina Bagherianlemraski, Zahra Taheri, Mohammad Mahdi Khanmohammadi, Simin Bina, Arghavan Kavousi, Sara Bagheri-Hosseini, Seyed Ali Mosaddad, Nozhan Azimi, Rubina Valipour, Seyed Mahmoud Atarodi, Niloofar Deravi\",\"doi\":\"10.1563/aaid-joi-D-23-00091\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>This systematic review investigates the probable effect of proton pump inhibitor (PPI) use on the severity of periodontal disease and peri-implantitis and implant survival. We conducted a literature search in PubMed, Scopus, and Cochrane Central Library up to April 2024. Two review authors independently screened the title and abstracts and then the full texts of retrieved studies. Observational and clinical trial studies that assessed the association between PPI use and periodontal disease severity and peri-implantitis or implant survival were included. Data extraction from the included studies was done by 2 reviewers independently. Of 940 studies initially retrieved from online searching, 7 met the inclusion criteria. Three studies examined periodontitis, whereas 4 focused on peri-implantitis and implant longevity. On the contrary, evidence regarding the impact of PPI use on peri-implantitis and implant survival is conflicting. Therefore, more well-designed randomized controlled trials are warranted to come to a definite conclusion. Because PPIs alter the gut microbiome and affect bone, plus that the pathogenesis and etiology of periodontal disease are affected by bacteria within the periodontal pocket, it is hypothesized that they may affect periodontal pathogenesis.</p>\",\"PeriodicalId\":519890,\"journal\":{\"name\":\"The Journal of oral implantology\",\"volume\":\" \",\"pages\":\"659-664\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Journal of oral implantology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1563/aaid-joi-D-23-00091\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Journal of oral implantology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1563/aaid-joi-D-23-00091","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Association Between Proton Pump Inhibitor Use and the Severity of Periodontal Disease and Peri-Implantitis: A Systematic Review.
This systematic review investigates the probable effect of proton pump inhibitor (PPI) use on the severity of periodontal disease and peri-implantitis and implant survival. We conducted a literature search in PubMed, Scopus, and Cochrane Central Library up to April 2024. Two review authors independently screened the title and abstracts and then the full texts of retrieved studies. Observational and clinical trial studies that assessed the association between PPI use and periodontal disease severity and peri-implantitis or implant survival were included. Data extraction from the included studies was done by 2 reviewers independently. Of 940 studies initially retrieved from online searching, 7 met the inclusion criteria. Three studies examined periodontitis, whereas 4 focused on peri-implantitis and implant longevity. On the contrary, evidence regarding the impact of PPI use on peri-implantitis and implant survival is conflicting. Therefore, more well-designed randomized controlled trials are warranted to come to a definite conclusion. Because PPIs alter the gut microbiome and affect bone, plus that the pathogenesis and etiology of periodontal disease are affected by bacteria within the periodontal pocket, it is hypothesized that they may affect periodontal pathogenesis.