甲状旁腺功能亢进症患者偶然摄入甲状腺18F-氟胆碱对定位甲状旁腺功能亢进的意义。

IF 1.3 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Nuclear Medicine Communications Pub Date : 2024-11-01 Epub Date: 2024-08-05 DOI:10.1097/MNM.0000000000001887
Hannes Grünig, Klaus Strobel, Andrea Zander, Maria Del Sol Pérez Lago, Thiago Lima, Corinna Wicke, Stefan Fischli, Ujwal Bhure
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引用次数: 0

摘要

目的:18F-氟胆碱 PET/CT 被认为是检测甲状旁腺功能亢进的成像金标准。然而,甲状腺也可能出现摄取增加的情况。我们的研究旨在评估甲状旁腺功能亢进症患者甲状腺摄取18F-氟胆碱的发生率和意义:这项回顾性研究包括195例连续接受18F-氟胆碱PET/CT检查的甲状旁腺功能亢进症患者。PET/CT 图像由两名核医学医生进行审查,以确定是否存在局灶性或弥漫性甲状腺摄取。将PET/CT结果与实验室参数、超声波检查、甲状腺结节的EU-TIRADS分类、细胞学检查和最终组织学检查进行比较。结果:25 名患者(13%)的甲状腺摄取了 18F-氟胆碱:7 名患者(4%)摄取了局灶性甲状腺摄取(FTU),8 名患者(4%)摄取了弥漫性甲状腺摄取(DTU),10 名患者(5%)联合摄取(FTU + DTU),共有 20 个活动性甲状腺结节。EU-TIRADS分类与PET参数之间没有相关性。一个18F-氟胆碱高度活跃的甲状腺结节和一个等活跃的甲状腺结节最终的组织学结果是甲状腺乳头状癌;50%的DTU患者患有桥本氏甲状腺炎:结论:13%的患者在甲状腺中意外摄取了18F-氟胆碱。正如18F-FDG的报告一样,局灶性18F-氟胆碱摄取可能代表甲状腺癌,应通过超声波进行评估,如有必要,还应做细针穿刺细胞学检查。弥漫性18F-氟胆碱摄取最有可能代表多结节性甲状腺肿或桥本氏甲状腺炎。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Significance of incidental thyroid 18 F-fluorocholine uptake in patients with hyperparathyroidism imaged for localizing hyperfunctioning parathyroid glands.

Objective: 18 F-fluorocholine PET/CT is considered the imaging gold standard for detection of hyperfunctioning parathyroid glands . However, increased uptake might also occur in the thyroid gland. The aim of our study was to assess the incidence and significance of 18 F-fluorocholine uptake in the thyroid gland in patients with hyperparathyroidism.

Materials and methods: This retrospective study includes 195 consecutive patients with hyperparathyroidism, who underwent 18 F-fluorocholine PET/CT, for detection of hyperfunctioning parathyroid glands. PET/CT images were reviewed by two nuclear medicine physicians for the presence of focal or diffuse thyroid uptake. PET/CT results were compared with laboratory parameters, ultrasonography, EU-TIRADS classification in the presence of thyroid nodules, cytology, and final histology.

Results: 25 patients (13%) showed 18 F-fluorocholine uptake in the thyroid gland: focal thyroid uptake (FTU) in 7 patients (4%), diffuse thyroid uptake (DTU) in 8 patients (4%), and combined uptake (FTU + DTU) in 10 patients (5%), with a total of 20 active thyroid nodules. There was no correlation between EU-TIRADS classification and PET parameters. One highly 18 F-fluorocholine active thyroid nodule and one isoactive thyroid nodule turned out to be papillary thyroid cancers in the final histology; 50% of the patients with DTU had Hashimoto's thyroiditis.

Conclusion: Incidental 18 F-fluorocholine uptake in the thyroid gland was observed in 13% of patients. As reported for 18 F-FDG, focal 18 F-fluorocholine uptake might represent thyroid cancer and should be evaluated with ultrasound and, if indicated, with fine-needle aspiration cytology. Diffuse 18 F-fluorocholine uptake most likely represents multinodular goiter or Hashimoto's thyroiditis.

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来源期刊
CiteScore
2.20
自引率
6.70%
发文量
212
审稿时长
3-8 weeks
期刊介绍: Nuclear Medicine Communications, the official journal of the British Nuclear Medicine Society, is a rapid communications journal covering nuclear medicine and molecular imaging with radionuclides, and the basic supporting sciences. As well as clinical research and commentary, manuscripts describing research on preclinical and basic sciences (radiochemistry, radiopharmacy, radiobiology, radiopharmacology, medical physics, computing and engineering, and technical and nursing professions involved in delivering nuclear medicine services) are welcomed, as the journal is intended to be of interest internationally to all members of the many medical and non-medical disciplines involved in nuclear medicine. In addition to papers reporting original studies, frankly written editorials and topical reviews are a regular feature of the journal.
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