定义神经母细胞瘤：从起源到精准医疗。

IF 16.4 1区医学 Q1 CLINICAL NEUROLOGY

Neuro-oncology Pub Date : 2024-08-05 DOI:10.1093/neuonc/noae152

Lourdes Sainero-Alcolado, Tomas Sjöberg Bexelius, Giuseppe Santopolo, Ye Yuan, Judit Liaño-Pons, Marie Arsenian-Henriksson

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引用次数: 0

摘要

神经母细胞瘤（NB）是小儿交感神经系统的一种异质性肿瘤，是婴儿中最常见、最致命的颅外实体瘤。人们在了解其起源和开发新型治疗性靶向疗法方面投入了大量精力。在此，我们总结了最近在确定起源细胞和导致 NB 的发育过程中发生的基因改变方面取得的进展。我们将讨论目前的治疗方案、新型治疗代谢靶点的目前和未来鉴定方向、分化药物以及个性化联合疗法，作为改善 NB 患儿生存和生活质量的潜在方法。

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Defining Neuroblastoma: from origin to precision medicine.

Neuroblastoma (NB), an heterogenous pediatric tumor of the sympathetic nervous system, is the most common and deadly extracranial solid malignancy diagnosed in infants. Numerous efforts have been invested in understanding its origin and in development of novel curative targeted therapies. Here, we summarize the recent advances in the identification of the cell of origin and the genetic alterations occurring during development contributing to NB. We discuss current treatment regimens, present and future directions for identification of novel therapeutic metabolic targets, differentiation agents, as well as personalized combinatory therapies as potential approaches for improving survival and quality of life of children with NB.

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来源期刊

Neuro-oncology 医学-临床神经学

CiteScore

27.20

自引率

6.30%

发文量

1434

审稿时长

3-8 weeks

期刊介绍： Neuro-Oncology, the official journal of the Society for Neuro-Oncology, has been published monthly since January 2010. Affiliated with the Japan Society for Neuro-Oncology and the European Association of Neuro-Oncology, it is a global leader in the field. The journal is committed to swiftly disseminating high-quality information across all areas of neuro-oncology. It features peer-reviewed articles, reviews, symposia on various topics, abstracts from annual meetings, and updates from neuro-oncology societies worldwide.