新型甾体选择性雄激素受体调节剂 (SARM) 化合物 S42 的气相色谱电子电离高分辨质谱综合研究。

IF 1.9 3区化学 Q3 BIOCHEMICAL RESEARCH METHODS

Journal of Mass Spectrometry Pub Date : 2024-08-05 DOI:10.1002/jms.5077

Hui-Chung Wen, Tobias Wilczek, Jörg-M. Neudörfl, Felicitas Wagener, Thomas Piper, Mario Thevis, Mathias Schäfer

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引用次数: 0

摘要

合成的 20 酮类固醇 S42 (1) 在临床前研究中表现出选择性雄激素受体调节剂 (SARM) 的特性，因此在运动药物测试项目中也受到越来越多的关注。要针对体液基质中的 S42 (1) 及其代谢物开发出可靠的定性和定量兴奋剂控制方法，就必须从根本上了解 S42 (1) 及其相关衍生物在高分辨率气相色谱-电子电离质谱（GC-EI-HRMS）实验中的行为。我们介绍了有关 S42 (1) 和硅醚衍生物以及稳定同位素标记参考物质的 EI 碎片行为的重要基础机理数据。

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A comprehensive gas chromatography electron ionization high resolution mass spectrometry study of a new steroidal selective androgen receptor modulator (SARM) compound S42

The synthetic 20-keto-steroid S42 (1) demonstrated selective androgen receptor modulator (SARM) properties in preclinical studies and, consequently, received growing attention also in the context of sports drug testing programs. Fundamental understanding of the behavior of S42 (1) and of relevant derivatives in gas chromatography-electron ionization MS experiments at high resolution (GC-EI-HRMS) is indispensable to develop a reliable qualitative and quantitative doping control method for S42 (1) and its metabolites in body fluid matrices. We present important fundamental mechanistic data on the EI fragmentation behavior of S42 (1) and of silyl ether derivatives as well as of stable isotope-labelled reference material.

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来源期刊

Journal of Mass Spectrometry 化学-光谱学

CiteScore

5.10

自引率

0.00%

发文量

审稿时长

1.5 months

期刊介绍： The Journal of Mass Spectrometry publishes papers on a broad range of topics of interest to scientists working in both fundamental and applied areas involving the study of gaseous ions. The aim of JMS is to serve the scientific community with information provided and arranged to help senior investigators to better stay abreast of new discoveries and studies in their own field, to make them aware of events and developments in associated fields, and to provide students and newcomers the basic tools with which to learn fundamental and applied aspects of mass spectrometry.