Yu Shi, Shijian Miao, Guomei Shen, Jin Fu, Xuan Gao, Xiaonan Du, Guoying Huang, Shuizhen Zhou, Xiaowen Zhai
{"title":"奥米克浪潮期间 COVID-19 热性惊厥患儿的临床和生化特征","authors":"Yu Shi, Shijian Miao, Guomei Shen, Jin Fu, Xuan Gao, Xiaonan Du, Guoying Huang, Shuizhen Zhou, Xiaowen Zhai","doi":"10.1055/s-0044-1788678","DOIUrl":null,"url":null,"abstract":"<p>\n<b>Objective</b> Mild symptoms are the norm for children with coronavirus disease-2019 (COVID-19), but data on the Omicron form are few. One of the most frequent neurological symptoms of COVID-19 in children is febrile seizure (FS).</p> <p>\n<b>Methods</b> Patients with FS who visited the pediatric fever clinic between December 6 and December 31, 2022, when the Omicron version of SARS-CoV-2 was the predominant strain, were included in this retrospective, single-center analysis.</p> <p>\n<b>Results</b> Children who tested positive for COVID-19 had a 5.58% incidence of FSs. Compared to patients without COVID-19, a greater percentage of COVID-19 patients (29.5 vs. 7.5%, <i>p</i> < 0.01) experienced complex FSs. In the COVID-19-positive group, four cases were critically unwell and were admitted to the Intensive Care Unit (1.4 vs. 0%, <i>p</i> < 0.01), and the admission proportion was greater (18.9 vs. 1.9%, <i>p</i> < 0.01). The proportion of lactic acid and IL-6 increase was larger in the COVID-19-positive group (33.5 vs. 21.5%, 22.1 vs. 17.8%, <i>p</i> = 0.022, <i>p</i> = 0.006, respectively).</p> <p>\n<b>Conclusion</b> Infections with COVID-19 in children have been linked to FSs in the Omicron era. To fully understand the neuropathogenesis of seizures in children with COVID-19, more research is required.</p> ","PeriodicalId":16739,"journal":{"name":"Journal of Pediatric infectious diseases","volume":"190 1","pages":""},"PeriodicalIF":0.2000,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Clinical and Biochemical Features of Kids with COVID-19 Febrile Seizures during the Omicron Wave\",\"authors\":\"Yu Shi, Shijian Miao, Guomei Shen, Jin Fu, Xuan Gao, Xiaonan Du, Guoying Huang, Shuizhen Zhou, Xiaowen Zhai\",\"doi\":\"10.1055/s-0044-1788678\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>\\n<b>Objective</b> Mild symptoms are the norm for children with coronavirus disease-2019 (COVID-19), but data on the Omicron form are few. One of the most frequent neurological symptoms of COVID-19 in children is febrile seizure (FS).</p> <p>\\n<b>Methods</b> Patients with FS who visited the pediatric fever clinic between December 6 and December 31, 2022, when the Omicron version of SARS-CoV-2 was the predominant strain, were included in this retrospective, single-center analysis.</p> <p>\\n<b>Results</b> Children who tested positive for COVID-19 had a 5.58% incidence of FSs. Compared to patients without COVID-19, a greater percentage of COVID-19 patients (29.5 vs. 7.5%, <i>p</i> < 0.01) experienced complex FSs. In the COVID-19-positive group, four cases were critically unwell and were admitted to the Intensive Care Unit (1.4 vs. 0%, <i>p</i> < 0.01), and the admission proportion was greater (18.9 vs. 1.9%, <i>p</i> < 0.01). The proportion of lactic acid and IL-6 increase was larger in the COVID-19-positive group (33.5 vs. 21.5%, 22.1 vs. 17.8%, <i>p</i> = 0.022, <i>p</i> = 0.006, respectively).</p> <p>\\n<b>Conclusion</b> Infections with COVID-19 in children have been linked to FSs in the Omicron era. To fully understand the neuropathogenesis of seizures in children with COVID-19, more research is required.</p> \",\"PeriodicalId\":16739,\"journal\":{\"name\":\"Journal of Pediatric infectious diseases\",\"volume\":\"190 1\",\"pages\":\"\"},\"PeriodicalIF\":0.2000,\"publicationDate\":\"2024-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Pediatric infectious diseases\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1055/s-0044-1788678\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Pediatric infectious diseases","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1055/s-0044-1788678","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
Clinical and Biochemical Features of Kids with COVID-19 Febrile Seizures during the Omicron Wave
Objective Mild symptoms are the norm for children with coronavirus disease-2019 (COVID-19), but data on the Omicron form are few. One of the most frequent neurological symptoms of COVID-19 in children is febrile seizure (FS).
Methods Patients with FS who visited the pediatric fever clinic between December 6 and December 31, 2022, when the Omicron version of SARS-CoV-2 was the predominant strain, were included in this retrospective, single-center analysis.
Results Children who tested positive for COVID-19 had a 5.58% incidence of FSs. Compared to patients without COVID-19, a greater percentage of COVID-19 patients (29.5 vs. 7.5%, p < 0.01) experienced complex FSs. In the COVID-19-positive group, four cases were critically unwell and were admitted to the Intensive Care Unit (1.4 vs. 0%, p < 0.01), and the admission proportion was greater (18.9 vs. 1.9%, p < 0.01). The proportion of lactic acid and IL-6 increase was larger in the COVID-19-positive group (33.5 vs. 21.5%, 22.1 vs. 17.8%, p = 0.022, p = 0.006, respectively).
Conclusion Infections with COVID-19 in children have been linked to FSs in the Omicron era. To fully understand the neuropathogenesis of seizures in children with COVID-19, more research is required.
期刊介绍：
The Journal of Pediatric Infectious Diseases is a peer-reviewed medical journal publishing articles in the field of child infectious diseases. The journal provides an in-depth update on new subjects and current comprehensive coverage of the latest techniques used in diagnosis and treatment of childhood infectious diseases.
The following articles will be considered for publication: editorials, original and review articles, rapid communications, letters to the editor and book reviews. The aim of the journal is to share and disseminate knowledge between all disciplines in the field of pediatric infectious diseases.
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