{"title":"慢性肾病与食管切除术后 30 天死亡率和发病率增加有关:倾向得分匹配研究","authors":"Renxi Li","doi":"10.1007/s10353-024-00835-0","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Background</h3><p>Chronic kidney disease (CKD) is one of the most prevalent comorbid conditions in the US. While prior studies have established a correlation between CKD and increased mortality and complications in surgery, its impact on esophagectomy outcomes remains underexplored. This study aimed to assess the effect of CKD on the 30-day outcomes of esophagectomy using data from a national registry.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>The American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) esophagectomy-targeted database was used in this retrospective study. The period considered was from 2016 to 2022. Patients with CKD were selected based on an estimated glomerular filtration rate (eGFR) ≤ 60 mL/min/1.73m<sup>2</sup>. A 1:2 propensity score matching was applied to CKD and non-CKD patients for demographics, baseline characteristics, neoadjuvant therapy, surgical approaches, tumor diagnosis, and staging of the malignancy. The 30-day postoperative outcomes were then compared.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>There were 655 (8.30%) and 7232 patients with and without CKD who underwent esophagectomy, respectively, whereby 1310 non-CKD patients were matched to all CKD patients. After propensity score matching, CKD patients had higher mortality (6.72% vs. 3.44%, <i>p</i> < 0.01), pulmonary complications (28.85% vs. 23.21%, <i>p</i> = 0.01), renal complications (7.18% vs. 2.44%, <i>p</i> < 0.01), sepsis (16.03% vs. 12.14%, <i>p</i> = 0.02), and bleeding requiring transfusion (16.64% vs. 12.06%, <i>p</i> = 0.01).</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>CKD can be an independent risk factor for adverse outcomes following esophagectomy. This underscores the importance of thorough preoperative risk stratification and the need for targeted management strategies for patients with CKD to potentially improve their surgical outcomes.</p>","PeriodicalId":12253,"journal":{"name":"European Surgery","volume":"188 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Chronic kidney disease is associated with increased 30-day mortality and morbidities after esophagectomy: a propensity score matched study\",\"authors\":\"Renxi Li\",\"doi\":\"10.1007/s10353-024-00835-0\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<h3 data-test=\\\"abstract-sub-heading\\\">Background</h3><p>Chronic kidney disease (CKD) is one of the most prevalent comorbid conditions in the US. While prior studies have established a correlation between CKD and increased mortality and complications in surgery, its impact on esophagectomy outcomes remains underexplored. This study aimed to assess the effect of CKD on the 30-day outcomes of esophagectomy using data from a national registry.</p><h3 data-test=\\\"abstract-sub-heading\\\">Methods</h3><p>The American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) esophagectomy-targeted database was used in this retrospective study. The period considered was from 2016 to 2022. Patients with CKD were selected based on an estimated glomerular filtration rate (eGFR) ≤ 60 mL/min/1.73m<sup>2</sup>. A 1:2 propensity score matching was applied to CKD and non-CKD patients for demographics, baseline characteristics, neoadjuvant therapy, surgical approaches, tumor diagnosis, and staging of the malignancy. The 30-day postoperative outcomes were then compared.</p><h3 data-test=\\\"abstract-sub-heading\\\">Results</h3><p>There were 655 (8.30%) and 7232 patients with and without CKD who underwent esophagectomy, respectively, whereby 1310 non-CKD patients were matched to all CKD patients. After propensity score matching, CKD patients had higher mortality (6.72% vs. 3.44%, <i>p</i> < 0.01), pulmonary complications (28.85% vs. 23.21%, <i>p</i> = 0.01), renal complications (7.18% vs. 2.44%, <i>p</i> < 0.01), sepsis (16.03% vs. 12.14%, <i>p</i> = 0.02), and bleeding requiring transfusion (16.64% vs. 12.06%, <i>p</i> = 0.01).</p><h3 data-test=\\\"abstract-sub-heading\\\">Conclusion</h3><p>CKD can be an independent risk factor for adverse outcomes following esophagectomy. This underscores the importance of thorough preoperative risk stratification and the need for targeted management strategies for patients with CKD to potentially improve their surgical outcomes.</p>\",\"PeriodicalId\":12253,\"journal\":{\"name\":\"European Surgery\",\"volume\":\"188 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-08-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European Surgery\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1007/s10353-024-00835-0\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Surgery","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s10353-024-00835-0","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
背景慢性肾病(CKD)是美国最普遍的合并症之一。虽然之前的研究已经证实了慢性肾脏病与手术死亡率和并发症增加之间的相关性,但其对食管切除术结果的影响仍未得到充分探讨。本研究旨在利用国家登记处的数据评估 CKD 对食管切除术 30 天预后的影响。方法本回顾性研究使用了美国外科学院国家外科质量改进计划(ACS-NSQIP)食管切除术目标数据库。研究时间为 2016 年至 2022 年。根据估计肾小球滤过率(eGFR)≤ 60 mL/min/1.73m2 的标准选择患有慢性肾脏病的患者。在人口统计学、基线特征、新辅助治疗、手术方法、肿瘤诊断和恶性肿瘤分期方面,对CKD和非CKD患者进行了1:2倾向得分匹配。结果分别有 655 名(8.30%)和 7232 名 CKD 患者和非 CKD 患者接受了食管切除术,其中 1310 名非 CKD 患者与所有 CKD 患者匹配。经过倾向评分匹配后,CKD 患者的死亡率(6.72% vs. 3.44%,p < 0.01)、肺部并发症(28.85% vs. 23.21%,p = 0.01)、肾脏并发症(7.18% vs. 2.44%,p < 0.01)、败血症(16.03% vs. 12.14%,P = 0.02)和需要输血的出血(16.64% vs. 12.06%,P = 0.01)。这强调了术前进行彻底风险分层的重要性,以及为 CKD 患者制定有针对性的管理策略以改善其手术效果的必要性。
Chronic kidney disease is associated with increased 30-day mortality and morbidities after esophagectomy: a propensity score matched study
Background
Chronic kidney disease (CKD) is one of the most prevalent comorbid conditions in the US. While prior studies have established a correlation between CKD and increased mortality and complications in surgery, its impact on esophagectomy outcomes remains underexplored. This study aimed to assess the effect of CKD on the 30-day outcomes of esophagectomy using data from a national registry.
Methods
The American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) esophagectomy-targeted database was used in this retrospective study. The period considered was from 2016 to 2022. Patients with CKD were selected based on an estimated glomerular filtration rate (eGFR) ≤ 60 mL/min/1.73m2. A 1:2 propensity score matching was applied to CKD and non-CKD patients for demographics, baseline characteristics, neoadjuvant therapy, surgical approaches, tumor diagnosis, and staging of the malignancy. The 30-day postoperative outcomes were then compared.
Results
There were 655 (8.30%) and 7232 patients with and without CKD who underwent esophagectomy, respectively, whereby 1310 non-CKD patients were matched to all CKD patients. After propensity score matching, CKD patients had higher mortality (6.72% vs. 3.44%, p < 0.01), pulmonary complications (28.85% vs. 23.21%, p = 0.01), renal complications (7.18% vs. 2.44%, p < 0.01), sepsis (16.03% vs. 12.14%, p = 0.02), and bleeding requiring transfusion (16.64% vs. 12.06%, p = 0.01).
Conclusion
CKD can be an independent risk factor for adverse outcomes following esophagectomy. This underscores the importance of thorough preoperative risk stratification and the need for targeted management strategies for patients with CKD to potentially improve their surgical outcomes.