从几分钟到几个月,运动对大脑健康和学习的影响:大脑 EXTEND 试验。

IF 2 3区 医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL
Michelle W. Voss , Chris Oehler , Will Daniels , Matthew Sodoma , Bryan Madero , James Kent , Shivangi Jain , Myungjin Jung , Virginia R. Nuckols , Lyndsey E. DuBose , Kristen G. Davis , Abby O'Deen , Chase Hamilton , Kelsey Baller , Jenna Springer , Adriana Rivera-Dompenciel , Marco Pipoly , Michael Muellerleile , Nagalakshmi Nagarajan , Thorarinn Bjarnason , Gary L. Pierce
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引用次数: 0

摘要

尽管有证据表明有氧运动有益于大脑老化,尤其是海马体和记忆,但对照临床试验尚未全面评估有氧运动训练对老年人记忆的影响。本研究的核心目标是确定中等强度到高强度的有氧运动对 55-80 岁非痴呆、不活动的成年人的海马体和记忆力的长期影响。我们通过一项为期 6 个月的随机对照试验(RCT)来确定有氧运动训练的效果,该试验将每周 150 分钟的家庭轻强度运动与循序渐进的中到大强度有氧运动进行了比较。在一项大型试验中,我们首次研究了时间机制,确定中等强度运动对海马-皮层连通性的快速、直接影响的个体差异是否能预测几个月后连通性和记忆中与长期训练相关的变化。我们通过测试与长期训练相关的心肺功能变化在多大程度上是影响记忆力的关键因素,对生理机制进行了研究。从几分钟到几个月的运动对大脑连通性和学习的影响(Brain-EXTEND)试验在概念上具有创新性,它采用了先进的海马依赖性学习和记忆过程测量方法,并对有氧运动引起的生理变化、遗传成分和分子变化进行了新颖的捕捉,从而改变了海马-皮层的连通性。鉴于海马连通性会随着阿尔茨海默氏症的恶化而恶化,而有氧运动可能有助于降低阿尔茨海默氏症的风险,我们的研究结果可以帮助人们了解有氧运动降低这种破坏性和代价高昂的疾病风险的生理机制和调节因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Exercise effects on brain health and learning from minutes to months: The brain EXTEND trial

Despite evidence that aerobic exercise benefits the aging brain, in particular the hippocampus and memory, controlled clinical trials have not comprehensively evaluated effects of aerobic exercise training on human memory in older adults. The central goal of this study was to determine chronic effects of moderate-to-vigorous intensity aerobic exercise on the hippocampus and memory in non-demented, inactive adults ages 55–80 years. We determine effects of aerobic exercise training with a 6-month randomized controlled trial (RCT) comparing 150 min/week of home-based, light intensity exercise with progressive moderate-to-vigorous intensity aerobic exercise. For the first time in a large trial, we examined temporal mechanisms by determining if individual differences in the rapid, immediate effects of moderate intensity exercise on hippocampal-cortical connectivity predict chronic training-related changes over months in connectivity and memory. We examined physiological mechanisms by testing the extent to which chronic training-related changes in cardiorespiratory fitness are a critical factor to memory benefits. The Exercise Effects on Brain Connectivity and Learning from Minutes to Months (Brain-EXTEND) trial is conceptually innovative with advanced measures of hippocampal-dependent learning and memory processes combined with novel capture of the physiological changes, genetic components, and molecular changes induced by aerobic exercise that change hippocampal-cortical connectivity. Given that hippocampal connectivity deteriorates with Alzheimer's and aerobic exercise may contribute to reduced risk of Alzheimer's, our results could lead to an understanding of the physiological mechanisms and moderators by which aerobic exercise reduces risk of this devastating and costly disease.

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来源期刊
CiteScore
3.70
自引率
4.50%
发文量
281
审稿时长
44 days
期刊介绍: Contemporary Clinical Trials is an international peer reviewed journal that publishes manuscripts pertaining to all aspects of clinical trials, including, but not limited to, design, conduct, analysis, regulation and ethics. Manuscripts submitted should appeal to a readership drawn from disciplines including medicine, biostatistics, epidemiology, computer science, management science, behavioural science, pharmaceutical science, and bioethics. Full-length papers and short communications not exceeding 1,500 words, as well as systemic reviews of clinical trials and methodologies will be published. Perspectives/commentaries on current issues and the impact of clinical trials on the practice of medicine and health policy are also welcome.
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