Michelle W. Voss , Chris Oehler , Will Daniels , Matthew Sodoma , Bryan Madero , James Kent , Shivangi Jain , Myungjin Jung , Virginia R. Nuckols , Lyndsey E. DuBose , Kristen G. Davis , Abby O'Deen , Chase Hamilton , Kelsey Baller , Jenna Springer , Adriana Rivera-Dompenciel , Marco Pipoly , Michael Muellerleile , Nagalakshmi Nagarajan , Thorarinn Bjarnason , Gary L. Pierce
{"title":"从几分钟到几个月,运动对大脑健康和学习的影响:大脑 EXTEND 试验。","authors":"Michelle W. Voss , Chris Oehler , Will Daniels , Matthew Sodoma , Bryan Madero , James Kent , Shivangi Jain , Myungjin Jung , Virginia R. Nuckols , Lyndsey E. DuBose , Kristen G. Davis , Abby O'Deen , Chase Hamilton , Kelsey Baller , Jenna Springer , Adriana Rivera-Dompenciel , Marco Pipoly , Michael Muellerleile , Nagalakshmi Nagarajan , Thorarinn Bjarnason , Gary L. Pierce","doi":"10.1016/j.cct.2024.107647","DOIUrl":null,"url":null,"abstract":"<div><p>Despite evidence that aerobic exercise benefits the aging brain, in particular the hippocampus and memory, controlled clinical trials have not comprehensively evaluated effects of aerobic exercise training on human memory in older adults. The central goal of this study was to determine chronic effects of moderate-to-vigorous intensity aerobic exercise on the hippocampus and memory in non-demented, inactive adults ages 55–80 years. We determine effects of aerobic exercise training with a 6-month randomized controlled trial (RCT) comparing 150 min/week of home-based, light intensity exercise with progressive moderate-to-vigorous intensity aerobic exercise. For the first time in a large trial, we examined temporal mechanisms by determining if individual differences in the rapid, immediate effects of moderate intensity exercise on hippocampal-cortical connectivity predict chronic training-related changes over months in connectivity and memory. We examined physiological mechanisms by testing the extent to which chronic training-related changes in cardiorespiratory fitness are a critical factor to memory benefits. The <em>Exercise Effects on Brain Connectivity and Learning from Minutes to Months</em> (Brain-EXTEND) trial is conceptually innovative with advanced measures of hippocampal-dependent learning and memory processes combined with novel capture of the physiological changes, genetic components, and molecular changes induced by aerobic exercise that change hippocampal-cortical connectivity. Given that hippocampal connectivity deteriorates with Alzheimer's and aerobic exercise may contribute to reduced risk of Alzheimer's, our results could lead to an understanding of the physiological mechanisms and moderators by which aerobic exercise reduces risk of this devastating and costly disease.</p></div>","PeriodicalId":10636,"journal":{"name":"Contemporary clinical trials","volume":null,"pages":null},"PeriodicalIF":2.0000,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Exercise effects on brain health and learning from minutes to months: The brain EXTEND trial\",\"authors\":\"Michelle W. Voss , Chris Oehler , Will Daniels , Matthew Sodoma , Bryan Madero , James Kent , Shivangi Jain , Myungjin Jung , Virginia R. Nuckols , Lyndsey E. DuBose , Kristen G. 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Exercise effects on brain health and learning from minutes to months: The brain EXTEND trial
Despite evidence that aerobic exercise benefits the aging brain, in particular the hippocampus and memory, controlled clinical trials have not comprehensively evaluated effects of aerobic exercise training on human memory in older adults. The central goal of this study was to determine chronic effects of moderate-to-vigorous intensity aerobic exercise on the hippocampus and memory in non-demented, inactive adults ages 55–80 years. We determine effects of aerobic exercise training with a 6-month randomized controlled trial (RCT) comparing 150 min/week of home-based, light intensity exercise with progressive moderate-to-vigorous intensity aerobic exercise. For the first time in a large trial, we examined temporal mechanisms by determining if individual differences in the rapid, immediate effects of moderate intensity exercise on hippocampal-cortical connectivity predict chronic training-related changes over months in connectivity and memory. We examined physiological mechanisms by testing the extent to which chronic training-related changes in cardiorespiratory fitness are a critical factor to memory benefits. The Exercise Effects on Brain Connectivity and Learning from Minutes to Months (Brain-EXTEND) trial is conceptually innovative with advanced measures of hippocampal-dependent learning and memory processes combined with novel capture of the physiological changes, genetic components, and molecular changes induced by aerobic exercise that change hippocampal-cortical connectivity. Given that hippocampal connectivity deteriorates with Alzheimer's and aerobic exercise may contribute to reduced risk of Alzheimer's, our results could lead to an understanding of the physiological mechanisms and moderators by which aerobic exercise reduces risk of this devastating and costly disease.
期刊介绍:
Contemporary Clinical Trials is an international peer reviewed journal that publishes manuscripts pertaining to all aspects of clinical trials, including, but not limited to, design, conduct, analysis, regulation and ethics. Manuscripts submitted should appeal to a readership drawn from disciplines including medicine, biostatistics, epidemiology, computer science, management science, behavioural science, pharmaceutical science, and bioethics. Full-length papers and short communications not exceeding 1,500 words, as well as systemic reviews of clinical trials and methodologies will be published. Perspectives/commentaries on current issues and the impact of clinical trials on the practice of medicine and health policy are also welcome.