从口腔到保护--通过口腔途径加强对新生儿疾病的免疫保护。

IF 4.7 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Molecular Biology Pub Date : 2024-07-31 DOI:10.1016/j.jmb.2024.168718

引用次数: 0

摘要

深入了解引导宿主免疫反应产生免疫原性或耐受性的机制对于包括疫苗接种在内的许多生物医学干预措施的成功至关重要1-10。在这方面，生命早期尤其值得关注，因为在人的一生中，婴幼儿不仅遭受的传染病负担最重，而且接种疫苗的次数也最多11-14。预防感染或疾病的疫苗是历史上最具成本效益的救生医疗干预措施之一15。包括新生儿在内的幼儿（小于 2 岁）接种了全球接种的大部分疫苗16。例如，世界卫生组织 (WHO) 扩大免疫规划 (EPI) 建议在婴儿出生后的头两年接种多达 9 种不同类型的疫苗（如减毒活疫苗、亚单位疫苗、佐剂疫苗等），但青少年和成人分别只接种 4 种和 3 种；建议 2 岁以下儿童接种 21-24 剂疫苗，而青少年只接种 7 剂，成人只接种 5 剂17。在本《视角》中，我们强调了在生命早期口服（per os (p.o.) = 经口）诱导免疫的独特性如何为在生命之初加强免疫介导的保护提供了极有前景的方法。口服途径还为公共卫生干预提供了一种更可行、更可扩展的方法，尤其是在资源有限的环境中18-21。因此，更加重视研究口服免疫调节干预措施（如疫苗）似乎是明智之举。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Per Os to Protection – Targeting the Oral Route to Enhance Immune-mediated Protection from Disease of the Human Newborn

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来源期刊

Journal of Molecular Biology 生物-生化与分子生物学

CiteScore

11.30

自引率

1.80%

发文量

412

审稿时长

28 days

期刊介绍： Journal of Molecular Biology (JMB) provides high quality, comprehensive and broad coverage in all areas of molecular biology. The journal publishes original scientific research papers that provide mechanistic and functional insights and report a significant advance to the field. The journal encourages the submission of multidisciplinary studies that use complementary experimental and computational approaches to address challenging biological questions. Research areas include but are not limited to: Biomolecular interactions, signaling networks, systems biology; Cell cycle, cell growth, cell differentiation; Cell death, autophagy; Cell signaling and regulation; Chemical biology; Computational biology, in combination with experimental studies; DNA replication, repair, and recombination; Development, regenerative biology, mechanistic and functional studies of stem cells; Epigenetics, chromatin structure and function; Gene expression; Membrane processes, cell surface proteins and cell-cell interactions; Methodological advances, both experimental and theoretical, including databases; Microbiology, virology, and interactions with the host or environment; Microbiota mechanistic and functional studies; Nuclear organization; Post-translational modifications, proteomics; Processing and function of biologically important macromolecules and complexes; Molecular basis of disease; RNA processing, structure and functions of non-coding RNAs, transcription; Sorting, spatiotemporal organization, trafficking; Structural biology; Synthetic biology; Translation, protein folding, chaperones, protein degradation and quality control.