[肺部疾病中的性别医学]

Chirurgie (Heidelberg, Germany) Pub Date : 2024-09-01 Epub Date: 2024-08-01 DOI:10.1007/s00104-024-02141-7
Laura V Klotz, Henrike Deissner, Florian Eichhorn
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引用次数: 0

摘要

在诊断和治疗各种肺部疾病时,必须考虑到性别差异。就气胸而言,除了病因上的差异外,男女在治疗和复发率上也存在相关差异。例如,为了降低复发率,诱发性气胸需要与妇科进行跨学科合作。近年来,肺癌的发病率已趋于平衡,此外,各种性别特异性预后因素也变得十分重要。多项荟萃分析表明,女性性别是肺癌的一个积极预后因素,此外,女性体内各种驱动基因突变的发生率也较高。在目前的肺癌多模式治疗试验中,耐受性和患者预后方面的性别差异已经很明显。在亚组分析中观察到,尽管免疫介导的不良反应在女性中更为常见,但女性的无事件生存率更高。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Gender medicine in lung diseases].

Gender-specific differences in the diagnostics and treatment must be considered for various lung diseases. In the case of pneumothorax, in addition to differences in etiology there are also relevant differences in treatment and recurrence rates between men and women. For example, to achieve low recurrence rates catamenial pneumothorax requires interdisciplinary collaboration with gynecology. The incidence of lung cancer has equalized in recent years and in addition, various gender-specific prognostic factors have become relevant. Several meta-analyses have identified female gender as a positive prognostic factor for lung cancer, in addition to the higher prevalence of various driver mutations in women. In current trials of multimodal treatment for lung cancer, gender differences in tolerability and patient outcome are already apparent. In subgroup analyses better event-free survival was observed in women, although immune-mediated adverse events were more common in women.

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