基于相位的结构化询问频域近红外光谱仪

Ola Abdalsalam, Scott Howard, Thomas D. O’Sullivan
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摘要

频域近红外光谱仪(FD-NIRS)是定量测量组织中光学吸收和散射的一种无创方法。本研究将结构化询问(SI)作为一种基于干涉的方法用于实施 FD-NIRS,以增强多层组织中的光学特性估计和对深层组织的灵敏度。我们发现,在存在实际噪声的情况下,SI 能准确估计属性和发色团浓度,误差小于 5%。尤其值得注意的是,SI FD-NIRS 的纯相位成分可以量化均质组织中的光吸收和减少的散射,与传统方法相比,对深层组织吸收变化的灵敏度提高了 20%。我们的研究表明,这种灵敏度的提高有望提高对表层污染较少的婴儿大脑皮层进行脑功能监测的准确性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Phase-based structured interrogation frequency-domain near-infrared spectroscopy
Frequency-domain near-infrared spectroscopy (FD-NIRS) is a noninvasive method for quantitatively measuring optical absorption and scattering in tissue. This study introduces structured interrogation (SI) as an interference-based approach for implementing FD-NIRS in order to enhance optical property estimation in multilayered tissues and sensitivity to deeper layers. We find that, in the presence of realistic noise, SI accurately estimates properties and chromophore concentrations with less than a 5% error. Particularly noteworthy, the phase-only component of SI FD-NIRS can quantify both the optical absorption and reduced scattering in homogeneous tissues and shows a 20% improved sensitivity to absorption changes in deeper tissues compared to conventional methods. We show that this enhanced sensitivity is promising for improving the accuracy of functional brain monitoring in the cortex of an infant with less superficial contamination.
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