CD73 对 NAD 代谢的调控：揭示肿瘤免疫与肿瘤代谢之间的相互作用

IF 8.2 2区生物学 Q1 CELL BIOLOGY

Cell Communication and Signaling Pub Date : 2024-08-01 DOI:10.1186/s12964-024-01755-y

Jianhao Zhan, Le Huang, Liyan Niu, Wenhui Lu, Chengpeng Sun, Shanshan Liu, Zijun Ding, Enliang Li

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引用次数: 0

摘要

CD73 是一种细胞表面结合的核苷酸酶，是一种重要的代谢和免疫检查点。多项研究表明，CD73 在免疫细胞上广泛表达，作为 T 细胞的成本刺激分子和腺苷生成因子，在免疫逃逸、细胞粘附和迁移中发挥着关键作用。然而，最近的研究发现，CD73 对原发肿瘤的影响并不仅限于抑制抗肿瘤免疫反应。烟酰胺腺嘌呤二核苷酸（NAD+）是生物体内一种重要的生物活性分子，在肿瘤内多种生物过程中发挥着重要的调节作用。越来越多的证据表明，CD73 参与了 NAD 的运输和代谢，从而调节肿瘤的生物过程，促进肿瘤的生长和增殖。本综述从整体上将 CD73 调控的 NAD + 代谢视为一个复杂的网络，并进一步强调了 CD73 作为癌症疗法新靶点的新作用。

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Regulation of CD73 on NAD metabolism: Unravelling the interplay between tumour immunity and tumour metabolism

CD73, a cell surface-bound nucleotidase, serves as a crucial metabolic and immune checkpoint. Several studies have shown that CD73 is widely expressed on immune cells and plays a critical role in immune escape, cell adhesion and migration as a costimulatory molecule for T cells and a factor in adenosine production. However, recent studies have revealed that the protumour effects of CD73 are not limited to merely inhibiting the antitumour immune response. Nicotinamide adenine dinucleotide (NAD+) is a vital bioactive molecule in organisms that plays essential regulatory roles in diverse biological processes within tumours. Accumulating evidence has demonstrated that CD73 is involved in the transport and metabolism of NAD, thereby regulating tumour biological processes to promote growth and proliferation. This review provides a holistic view of CD73-regulated NAD + metabolism as a complex network and further highlights the emerging roles of CD73 as a novel target for cancer therapies.

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来源期刊

Cell Communication and Signaling CELL BIOLOGY-

CiteScore

11.00

自引率

0.00%

发文量

180

期刊介绍： Cell Communication and Signaling (CCS) is a peer-reviewed, open-access scientific journal that focuses on cellular signaling pathways in both normal and pathological conditions. It publishes original research, reviews, and commentaries, welcoming studies that utilize molecular, morphological, biochemical, structural, and cell biology approaches. CCS also encourages interdisciplinary work and innovative models, including in silico, in vitro, and in vivo approaches, to facilitate investigations of cell signaling pathways, networks, and behavior. Starting from January 2019, CCS is proud to announce its affiliation with the International Cell Death Society. The journal now encourages submissions covering all aspects of cell death, including apoptotic and non-apoptotic mechanisms, cell death in model systems, autophagy, clearance of dying cells, and the immunological and pathological consequences of dying cells in the tissue microenvironment.