探索有毒金属暴露与多动症之间的联系：对铅和汞的系统研究

IF 4.1 2区医学 Q1 CLINICAL NEUROLOGY

Journal of Neurodevelopmental Disorders Pub Date : 2024-08-01 DOI:10.1186/s11689-024-09555-8

Reyhane Farmani, Omid Mehrpour, Alireza Kooshki, Samaneh Nakhaee

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引用次数: 0

摘要

注意力缺陷/多动障碍（ADHD）是一种公认的神经发育障碍，其病因复杂且多因素。铅（Pb）和汞（Hg）是剧毒物质，可能会损害大脑发育，并与多动症的发病有关。本系统性综述旨在分析有关铅和汞暴露与多动症诊断之间关系的流行病学文献。自 1983 年 11 月至 2023 年 6 月 2 日，我们在多个数据库和搜索引擎中进行了全面检索，包括 PubMed、Web of Science、Scopus 和 Google Scholar。纳入了测量多动症儿童或其父母各种生物样本（血液、毛发、尿液、指甲、唾液、牙齿和骨骼）中铅和汞水平及其与多动症症状关系的观察性研究（病例对照、队列和横断面）。在 2059 项研究中，有 87 项符合纳入标准，被纳入本系统综述。在调查不同生物样本中铅含量的 74 项研究中，约有三分之二的研究报告了铅含量与至少一种亚型多动症的关系。然而，对不同生物样本中汞含量进行检测的大多数研究发现，尽管接触时间和诊断标准不同，但汞含量与任何一种多动症亚型均无明显关联。从纳入的研究中收集到的证据支持铅暴露与多动症诊断之间存在关联，而汞暴露则没有发现明显关联。重要的是，即使是低水平的铅暴露也会增加多动症的风险。考虑到儿童多动症作为一种神经发育障碍的重要性，还需要进一步的研究来探索儿童多动症的各种风险因素。

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Exploring the link between toxic metal exposure and ADHD: a systematic review of pb and hg

Attention-Deficit/Hyperactivity Disorder (ADHD) is a recognized neurodevelopmental disorder with a complex, multifactorial origin. Lead (Pb) and mercury (Hg) are highly toxic substances that can potentially impair brain development and have been implicated in the development of ADHD. This systematic review aims to analyze the epidemiological literature regarding the association between Pb and Hg exposure and the diagnosis of ADHD. From November 1983 to June 2, 2023, a comprehensive search was conducted in multiple databases and search engines, including PubMed, Web of Science, Scopus, and Google Scholar. Observational studies (case-control, cohort, and cross-sectional) measuring Pb and Hg levels in various biological samples (blood, hair, urine, nail, saliva, teeth, and bone) of children with ADHD or their parents and their association with ADHD symptoms were included. Out of 2059 studies, 87 met the inclusion criteria and were included in this systematic review. Approximately two-thirds of the 74 studies investigating Pb levels in different biological samples reported associations with at least one subtype of ADHD. However, most studies examining Hg levels in various biological samples found no significant association with any ADHD subtype, although there were variations in exposure periods and diagnostic criteria. The evidence gathered from the included studies supports an association between Pb exposure and the diagnosis of ADHD, while no significant association was found with Hg exposure. Importantly, even low levels of Pb were found to elevate the risk of ADHD. Further research is needed to explore the comprehensive range of risk factors for ADHD in children, considering its significance as a neurodevelopmental disorder.

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来源期刊

Journal of Neurodevelopmental Disorders 医学-临床神经学

CiteScore

7.60

自引率

4.10%

发文量

审稿时长

>12 weeks

期刊介绍： Journal of Neurodevelopmental Disorders is an open access journal that integrates current, cutting-edge research across a number of disciplines, including neurobiology, genetics, cognitive neuroscience, psychiatry and psychology. The journal’s primary focus is on the pathogenesis of neurodevelopmental disorders including autism, fragile X syndrome, tuberous sclerosis, Turner Syndrome, 22q Deletion Syndrome, Prader-Willi and Angelman Syndrome, Williams syndrome, lysosomal storage diseases, dyslexia, specific language impairment and fetal alcohol syndrome. With the discovery of specific genes underlying neurodevelopmental syndromes, the emergence of powerful tools for studying neural circuitry, and the development of new approaches for exploring molecular mechanisms, interdisciplinary research on the pathogenesis of neurodevelopmental disorders is now increasingly common. Journal of Neurodevelopmental Disorders provides a unique venue for researchers interested in comparing and contrasting mechanisms and characteristics related to the pathogenesis of the full range of neurodevelopmental disorders, sharpening our understanding of the etiology and relevant phenotypes of each condition.