由含偶氮苯的芳香族酰胺驱动的 H+/X- 协同传输

IF 3 4区化学 Q3 CHEMISTRY, PHYSICAL

ChemPhotoChem Pub Date : 2024-07-30 DOI:10.1002/cptc.202400179

Sameer Ahmad Malik, Nandita Madhavan

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引用次数: 0

摘要

细胞膜上的天然离子转运体在维持细胞平衡方面发挥着关键作用。合成离子转运体是了解和解决天然转运体功能障碍的极具吸引力的模型系统。在这里，一种由偶氮苯和间氨基苯甲酸衍生的简单酰胺实现了脂膜上的光调节离子转运。这种酰胺能形成孔隙或通道，选择性地共同传输 H+/X- 跨脂膜。由于顺式异构体的质子亲和力更高，因此从反式到顺式的光异构化会使离子传输速率提高 2 倍。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

H+/X− Co-Transport Driven by Azobenzene Containing Aromatic Amides

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H+/X− Co-Transport Driven by Azobenzene Containing Aromatic Amides

Natural ion-transporters in cellular membranes play a critical role in maintaining cell homeostasis. Synthetic ion-transporters are attractive model systems for understanding and addressing dysfunction of natural transporters. Herein, a simple amide derived from azobenzene and m-aminobenzoic acid achieves photoregulated ion transport across lipid membranes. The amide forms pores or channels that selectively co-transport H⁺/X⁻ across the lipid membrane. Photoisomerization from the trans to cis form results in a 2-fold increase in ion-transport rates due to the higher proton affinity of the cis isomer.

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来源期刊

ChemPhotoChem Chemistry-Physical and Theoretical Chemistry

CiteScore

5.80

自引率

5.40%

发文量

165

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