通过依那普利靶向血管紧张素转换酶抑制剂可减少手术后粘连带的形成

IF 1.2 4区 医学 Q4 CHEMISTRY, MEDICINAL
Sanaz Majnoon, Fereshteh Asgharzadeh, Reihaneh Sabbaghzadeh, Seyede Elnaz Nazari, Zahra Yarmohammadi, Nikoo Saeedi, Seyed Mahdi Hassanian, Gordon Ferns, Majid Khazaei, Amir Avan
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引用次数: 0

摘要

背景:腹部手术后通常会发生术后粘连,并可能导致严重的并发症。越来越多的证据表明,以肾素-血管紧张素系统(RAS)为靶点可减轻炎症和纤维化。本研究探讨了 RAS 抑制剂依那普利在大鼠术后粘连带形成模型中的治疗潜力。研究方法12 只雄性白化 Wistar 大鼠腹腔注射依那普利(10 毫克/千克)。9 天后,使用 RTPCR 和 ELISA 以及苏木精、伊红和马森三色染色法评估其抗炎和抗纤维化作用。结果:统计分析结果表明,依那普利能显著降低粘连带的频率和稳定性。它通过抑制促炎细胞因子、减少促炎细胞浸润和抑制腹膜手术部位的氧化应激,减轻了粘膜下水肿。此外,依那普利通过减少胶原沉积和抑制腹膜粘连组织中的促纤维化基因表达,抑制了纤维化粘连带的形成。结论这些研究结果证明了依那普利通过抑制炎症和纤维化的关键病理反应来预防术后粘连带形成的治疗潜力,支持将其用作术后粘连管理的预防性治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Targeting Angiotensin-converting Enzyme Inhibitor via Enalapril Reduces Postsurgical Adhesion Band Formation
Background: Postoperative adhesions commonly occur after abdominal surgery and can lead to significant complications. There is increasing evidence that targeting the renin-angiotensin system (RAS) can reduce inflammation and fibrosis. This study investigates the therapeutic potential of enalapril, an RAS inhibitor, in a rat model of postsurgical adhesion band formation. Methods: A total of 12 male albino Wistar rats received intraperitoneal administration of enalapril (10 mg/kg). After 9 days, the anti-inflammatory and antifibrotic effects were evaluated using RTPCR and ELISA, alongside hematoxylin and eosin and Masson's trichrome staining. Result: The statistical analysis of findings showed that enalapril significantly reduced the frequency and stability of adhesion bands. It attenuated submucosal edema by suppressing pro-inflammatory cytokines, decreasing pro-inflammatory cell infiltration, and inhibiting oxidative stress at the peritoneal surgery site. Additionally, enalapril inhibited fibrotic adhesion band formation by reducing collagen deposition and suppressing the expression of profibrotic genes in peritoneal adhesion tissues. Conclusion: These findings demonstrate the therapeutic potential of enalapril in preventing postsurgical adhesion band formation by inhibiting key pathological responses of inflammation and fibrosis, supporting its use as a preventive treatment in postoperative adhesion management.
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来源期刊
CiteScore
1.80
自引率
10.00%
发文量
245
审稿时长
3 months
期刊介绍: Aims & Scope Letters in Drug Design & Discovery publishes letters, mini-reviews, highlights and guest edited thematic issues in all areas of rational drug design and discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, and structure-activity relationships. The emphasis is on publishing quality papers very rapidly by taking full advantage of latest Internet technology for both submission and review of manuscripts. The online journal is an essential reading to all pharmaceutical scientists involved in research in drug design and discovery.
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