PEER 超高剂量率、超高能量电子辐照环境下的 MOSkin 剂量测量法

IF 1.9 3区 物理与天体物理 Q2 PHYSICS, MULTIDISCIPLINARY
James Cayley, Yaw-Ren E. Tan, Marco Petasecca, Dean Cutajar, Thomas Breslin, Anatoly Rosenfeld, Michael Lerch
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引用次数: 0

摘要

FLASH 放射治疗是指以超高剂量率(UHDRs)进行放射治疗,已在各种形式的放射治疗中得到证实,也是近期研究和开发的热点,包括使用超高能电子(VHEEs)治疗深部肿瘤。在临床环境中进行 FLASH 放射治疗预计会对实时质量保证和剂量测定系统提出很高的要求。此外,超高能电子研究目前需要将现有的非医用加速器改造成放射治疗研究环境。精确的剂量测定对于任何此类改造都至关重要。在本文中,我们将评估由医用辐射物理中心开发的MOSkin的响应情况,该系统设计用于在放疗过程中对患者进行实时皮肤剂量测量,当暴露在用于研究的脉冲高能电子(PEER)终端站的100兆电子束中时,MOSkin是否表现出剂量率独立性。PEER 在不用作 ANSTO 澳大利亚同步加速器的注入器时,使用 100 MeV 直线加速器的电子束。脉冲剂量率估计范围为(7.84±0.21)×105 Gy/s到(1.28±0.03)×107 Gy/s,峰值束剂量率估计为(2.55±0.06)×108 Gy/s,MOSkin测量结果与闪烁屏进行了验证,以确认MOSkin对输送电荷的反应成正比,因此在这种辐照环境下表现出剂量率独立性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
MOSkin dosimetry for an ultra-high dose-rate, very high-energy electron irradiation environment at PEER
FLASH radiotherapy, which refers to the delivery of radiation at ultra-high dose-rates (UHDRs), has been demonstrated with various forms of radiation and is the subject of intense research and development recently, including the use of very high-energy electrons (VHEEs) to treat deep-seated tumors. Delivering FLASH radiotherapy in a clinical setting is expected to place high demands on real-time quality assurance and dosimetry systems. Furthermore, very high-energy electron research currently requires the transformation of existing non-medical accelerators into radiotherapy research environments. Accurate dosimetry is crucial for any such transformation. In this article, we assess the response of the MOSkin, developed by the Center for Medical Radiation Physics, which is designed for on-patient, real-time skin dose measurements during radiotherapy, and whether it exhibits dose-rate independence when exposed to 100 MeV electron beams at the Pulsed Energetic Electrons for Research (PEER) end-station. PEER utilizes the electron beam from a 100 MeV linear accelerator when it is not used as the injector for the ANSTO Australian Synchrotron. With the estimated pulse dose-rates ranging from (7.84±0.21)×105 Gy/s to (1.28±0.03)×107 Gy/s and an estimated peak bunch dose-rate of (2.55±0.06)×108 Gy/s, MOSkin measurements were verified against a scintillating screen to confirm that the MOSkin responds proportionally to the charge delivered and, therefore, exhibits dose-rate independence in this irradiation environment.
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来源期刊
Frontiers in Physics
Frontiers in Physics Mathematics-Mathematical Physics
CiteScore
4.50
自引率
6.50%
发文量
1215
审稿时长
12 weeks
期刊介绍: Frontiers in Physics publishes rigorously peer-reviewed research across the entire field, from experimental, to computational and theoretical physics. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, engineers and the public worldwide.
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