辅助诊断运动相关脑震荡的次日血清胶质纤维酸性蛋白水平

medRxiv - Neurology Pub Date : 2024-08-01 DOI:10.1101/2024.07.31.24310616

William T O'Brien, James W Hickey, Steven Mutimer, Lauren J Evans, Blake D Colman, Becca Xie, Lauren P Giesler, Brendan P Major, Biswadev Mitra, Gershon Spitz, Terence J O'Brien, Sandy R Shultz, Stuart J McDonald

{"title":"辅助诊断运动相关脑震荡的次日血清胶质纤维酸性蛋白水平","authors":"William T O'Brien, James W Hickey, Steven Mutimer, Lauren J Evans, Blake D Colman, Becca Xie, Lauren P Giesler, Brendan P Major, Biswadev Mitra, Gershon Spitz, Terence J O'Brien, Sandy R Shultz, Stuart J McDonald","doi":"10.1101/2024.07.31.24310616","DOIUrl":null,"url":null,"abstract":"The diagnostic utility of blood glial fibrillary acidic protein (GFAP) in sport-related concussion (SRC) is unclear. This study measured serum GFAP at either 16-24 hours (h), 24-32h, or 36-52h post-SRC in 156 Australian football players and compared levels with 98 control players without SRC. Median GFAP levels were higher in SRC cases at 16-24h (124.7 pg/mL; p<0.001) and 24-32h (96.2 pg/mL; p<0.001) compared to controls (66.0 pg/mL), but not at 36-52h (62.8 pg/mL). GFAP had an area under the curve of 0.83 at 16-24h and 0.72 at 24-32h. Serum GFAP at 16-24h can be a useful aid in SRC diagnosis.","PeriodicalId":501367,"journal":{"name":"medRxiv - Neurology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Next-day Serum Glial Fibrillary Acidic Protein Levels to Aid Diagnosis of Sport-Related Concussion\",\"authors\":\"William T O'Brien, James W Hickey, Steven Mutimer, Lauren J Evans, Blake D Colman, Becca Xie, Lauren P Giesler, Brendan P Major, Biswadev Mitra, Gershon Spitz, Terence J O'Brien, Sandy R Shultz, Stuart J McDonald\",\"doi\":\"10.1101/2024.07.31.24310616\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The diagnostic utility of blood glial fibrillary acidic protein (GFAP) in sport-related concussion (SRC) is unclear. This study measured serum GFAP at either 16-24 hours (h), 24-32h, or 36-52h post-SRC in 156 Australian football players and compared levels with 98 control players without SRC. Median GFAP levels were higher in SRC cases at 16-24h (124.7 pg/mL; p<0.001) and 24-32h (96.2 pg/mL; p<0.001) compared to controls (66.0 pg/mL), but not at 36-52h (62.8 pg/mL). GFAP had an area under the curve of 0.83 at 16-24h and 0.72 at 24-32h. Serum GFAP at 16-24h can be a useful aid in SRC diagnosis.\",\"PeriodicalId\":501367,\"journal\":{\"name\":\"medRxiv - Neurology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"medRxiv - Neurology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1101/2024.07.31.24310616\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"medRxiv - Neurology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1101/2024.07.31.24310616","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

摘要

血液神经胶质纤维酸性蛋白（GFAP）对运动相关脑震荡（SRC）的诊断作用尚不明确。本研究测量了 156 名澳大利亚足球运动员在运动相关脑震荡后 16-24 小时、24-32 小时或 36-52 小时的血清神经胶质纤维酸性蛋白水平，并将其与 98 名无运动相关脑震荡的对照组球员的血清神经胶质纤维酸性蛋白水平进行了比较。与对照组（66.0 pg/mL）相比，SRC 病例在 16-24 小时（124.7 pg/mL；p<0.001）和 24-32 小时（96.2 pg/mL；p<0.001）的 GFAP 中位数水平较高，但在 36-52 小时（62.8 pg/mL）则不高。在 16-24 小时和 24-32 小时，GFAP 的曲线下面积分别为 0.83 和 0.72。16-24小时的血清GFAP可作为诊断SRC的有效辅助指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Next-day Serum Glial Fibrillary Acidic Protein Levels to Aid Diagnosis of Sport-Related Concussion

The diagnostic utility of blood glial fibrillary acidic protein (GFAP) in sport-related concussion (SRC) is unclear. This study measured serum GFAP at either 16-24 hours (h), 24-32h, or 36-52h post-SRC in 156 Australian football players and compared levels with 98 control players without SRC. Median GFAP levels were higher in SRC cases at 16-24h (124.7 pg/mL; p<0.001) and 24-32h (96.2 pg/mL; p<0.001) compared to controls (66.0 pg/mL), but not at 36-52h (62.8 pg/mL). GFAP had an area under the curve of 0.83 at 16-24h and 0.72 at 24-32h. Serum GFAP at 16-24h can be a useful aid in SRC diagnosis.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

medRxiv - Neurology

自引率

0.00%

发文量