基于粪便的大肠病变检测对普通风险人群的诊断效果：真实世界证据研究

IF 2.8 4区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Journal of clinical gastroenterology Pub Date : 2024-08-01 DOI:10.1097/MCG.0000000000002053

Catherine Cheney, Alice Parish, Donna Niedzwiecki, Chukwuemeka Oko, Christy Walters, Brian A Sullivan

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引用次数: 0

摘要

目的我们评估了粪便检验（SBT）在结直肠癌筛查中的实际表现：对随访结肠镜检查时发现晚期肿瘤（腺癌、晚期腺瘤和/或晚期锯齿状病变）的 SBT 阳性的平均风险人群进行回顾性研究：不同 SBT 对晚期肿瘤的检出率无统计学差异（P= 0.16）[多靶向粪便 DNA（mt-sDNA）为 30.7%，粪便免疫化学检测为 22.8%]。然而，在晚期锯齿状病变的检出率方面却存在显著差异（mt-sDNA 检测为 11.3% vs 粪便免疫化学检测为 1.8%，P< 0.001）：结论：尽管 mt-sDNA 检测出的晚期锯齿状病变明显多于粪便免疫化学检测，但两种 SBT 检测晚期肿瘤的结果没有差异。

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Diagnostic Performance of Stool-based Testing for Colorectal Lesions Among Average-risk Individuals: A Real-world Evidence Study.

Objective: We assessed the real-world performance of stool-based tests (SBTs) for colorectal cancer screening.

Materials and methods: Retrospective review of average-risk individuals with positive SBT for advanced neoplasia (adenocarcinoma, advanced adenoma, and/or advanced serrated lesions) detection at follow-up colonoscopy.

Results: There was no statistical difference in the detection of advanced neoplasia (P= 0.16) between SBTs [30.7% for multitargeted stool DNA (mt-sDNA) vs 22.8% for fecal immunochemical test]. However, there was a significant difference in the detection of advanced serrated lesions (11.3% for mt-sDNA vs 1.8% for fecal immunochemical test, P< 0.001).

Conclusion: There was no difference between SBTs for advanced neoplasia detection, though mt-sDNA detected significantly more advanced serrated lesions.

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来源期刊

Journal of clinical gastroenterology 医学-胃肠肝病学

CiteScore

5.60

自引率

3.40%

发文量

339

审稿时长

3-8 weeks

期刊介绍： Journal of Clinical Gastroenterology gathers the world''s latest, most relevant clinical studies and reviews, case reports, and technical expertise in a single source. Regular features include cutting-edge, peer-reviewed articles and clinical reviews that put the latest research and development into the context of your practice. Also included are biographies, focused organ reviews, practice management, and therapeutic recommendations.