Jing Liang, Yongfei Li, Panpan Wan, Wenjing Zhang, Junhui Han, Man Zhang, Bin Li, Tianbo Jin
{"title":"中国汉族人群中的 CYP19A1 多态性与膀胱癌风险。","authors":"Jing Liang, Yongfei Li, Panpan Wan, Wenjing Zhang, Junhui Han, Man Zhang, Bin Li, Tianbo Jin","doi":"10.1080/14737159.2024.2387652","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The expression of <i>CYP19A1</i> has implications for the prognosis of female bladder cancer. However, this study aimed to explore the association between single nucleotide polymorphisms (SNPs) in <i>CYP19A1</i> and bladder cancer risk, as no prior research has addressed this association.</p><p><strong>Research design and methods: </strong>We selected and genotyped five <i>CYP19A1</i> SNPs (rs4646, rs6493487, rs1062033, rs17601876, and rs3751599) in 217 patients and 550 controls using the Agena MassARRAY system. Logistic regression analysis was employed to calculate the odds ratio (OR) and 95% confidence intervals (CIs). Bioinformatics predicted SNP functions and <i>CYP19A1</i> involving pathways.</p><p><strong>Results: </strong>Our study revealed a significant association between bladder cancer risk and four SNPs (rs4646 (AC vs. CC: OR = 1.71, FDR-<i>p</i> = 0.005), rs6493487 (G vs. A: OR = 0.68, FDR-<i>p</i> = 0.011), rs1062033 (G vs. C: OR = 0.36, FDR-<i>p</i> < 0.001), and rs17601876 (GA vs. GG: OR = 1.66, FDR-<i>p</i> = 0.008)) in <i>CYP19A1</i>. The three SNPs (rs4646, rs1062033, and rs17601876) were significantly correlated with <i>CYP19A1</i> expression levels in normal whole blood (<i>p</i> < 0.05). Moreover, <i>CYP19A1</i> was found to primarily participate in the steroid hormone biosynthesis and metabolic pathways.</p><p><strong>Conclusions: </strong>Consequently, <i>CYP19A1</i> gene polymorphisms may play a crucial role in the genetic susceptibility to bladder cancer.</p>","PeriodicalId":12113,"journal":{"name":"Expert Review of Molecular Diagnostics","volume":null,"pages":null},"PeriodicalIF":3.9000,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"<i>CYP19A1</i> polymorphisms and bladder cancer risk in the Chinese Han population.\",\"authors\":\"Jing Liang, Yongfei Li, Panpan Wan, Wenjing Zhang, Junhui Han, Man Zhang, Bin Li, Tianbo Jin\",\"doi\":\"10.1080/14737159.2024.2387652\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>The expression of <i>CYP19A1</i> has implications for the prognosis of female bladder cancer. However, this study aimed to explore the association between single nucleotide polymorphisms (SNPs) in <i>CYP19A1</i> and bladder cancer risk, as no prior research has addressed this association.</p><p><strong>Research design and methods: </strong>We selected and genotyped five <i>CYP19A1</i> SNPs (rs4646, rs6493487, rs1062033, rs17601876, and rs3751599) in 217 patients and 550 controls using the Agena MassARRAY system. Logistic regression analysis was employed to calculate the odds ratio (OR) and 95% confidence intervals (CIs). Bioinformatics predicted SNP functions and <i>CYP19A1</i> involving pathways.</p><p><strong>Results: </strong>Our study revealed a significant association between bladder cancer risk and four SNPs (rs4646 (AC vs. CC: OR = 1.71, FDR-<i>p</i> = 0.005), rs6493487 (G vs. A: OR = 0.68, FDR-<i>p</i> = 0.011), rs1062033 (G vs. C: OR = 0.36, FDR-<i>p</i> < 0.001), and rs17601876 (GA vs. GG: OR = 1.66, FDR-<i>p</i> = 0.008)) in <i>CYP19A1</i>. The three SNPs (rs4646, rs1062033, and rs17601876) were significantly correlated with <i>CYP19A1</i> expression levels in normal whole blood (<i>p</i> < 0.05). Moreover, <i>CYP19A1</i> was found to primarily participate in the steroid hormone biosynthesis and metabolic pathways.</p><p><strong>Conclusions: </strong>Consequently, <i>CYP19A1</i> gene polymorphisms may play a crucial role in the genetic susceptibility to bladder cancer.</p>\",\"PeriodicalId\":12113,\"journal\":{\"name\":\"Expert Review of Molecular Diagnostics\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.9000,\"publicationDate\":\"2024-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Expert Review of Molecular Diagnostics\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/14737159.2024.2387652\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/8/5 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"PATHOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Expert Review of Molecular Diagnostics","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/14737159.2024.2387652","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/8/5 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"PATHOLOGY","Score":null,"Total":0}
CYP19A1 polymorphisms and bladder cancer risk in the Chinese Han population.
Background: The expression of CYP19A1 has implications for the prognosis of female bladder cancer. However, this study aimed to explore the association between single nucleotide polymorphisms (SNPs) in CYP19A1 and bladder cancer risk, as no prior research has addressed this association.
Research design and methods: We selected and genotyped five CYP19A1 SNPs (rs4646, rs6493487, rs1062033, rs17601876, and rs3751599) in 217 patients and 550 controls using the Agena MassARRAY system. Logistic regression analysis was employed to calculate the odds ratio (OR) and 95% confidence intervals (CIs). Bioinformatics predicted SNP functions and CYP19A1 involving pathways.
Results: Our study revealed a significant association between bladder cancer risk and four SNPs (rs4646 (AC vs. CC: OR = 1.71, FDR-p = 0.005), rs6493487 (G vs. A: OR = 0.68, FDR-p = 0.011), rs1062033 (G vs. C: OR = 0.36, FDR-p < 0.001), and rs17601876 (GA vs. GG: OR = 1.66, FDR-p = 0.008)) in CYP19A1. The three SNPs (rs4646, rs1062033, and rs17601876) were significantly correlated with CYP19A1 expression levels in normal whole blood (p < 0.05). Moreover, CYP19A1 was found to primarily participate in the steroid hormone biosynthesis and metabolic pathways.
Conclusions: Consequently, CYP19A1 gene polymorphisms may play a crucial role in the genetic susceptibility to bladder cancer.
期刊介绍：
Expert Review of Molecular Diagnostics (ISSN 1473-7159) publishes expert reviews of the latest advancements in the field of molecular diagnostics including the detection and monitoring of the molecular causes of disease that are being translated into groundbreaking diagnostic and prognostic technologies to be used in the clinical diagnostic setting.
Each issue of Expert Review of Molecular Diagnostics contains leading reviews on current and emerging topics relating to molecular diagnostics, subject to a rigorous peer review process; editorials discussing contentious issues in the field; diagnostic profiles featuring independent, expert evaluations of diagnostic tests; meeting reports of recent molecular diagnostics conferences and key paper evaluations featuring assessments of significant, recently published articles from specialists in molecular diagnostic therapy.
Expert Review of Molecular Diagnostics provides the forum for reporting the critical advances being made in this ever-expanding field, as well as the major challenges ahead in their clinical implementation. The journal delivers this information in concise, at-a-glance article formats: invaluable to a time-constrained community.
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