彭博利珠单抗联合阿西替尼和贝珠单抗联合伦伐替尼治疗肾细胞癌后的心肌炎:病例报告。

IF 3.4 3区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS
Cardiovascular Toxicology Pub Date : 2024-11-01 Epub Date: 2024-07-31 DOI:10.1007/s12012-024-09906-w
Andrea Villatore, Carlo Bosi, Chiara Pomaranzi, Antonio Cigliola, Valentina Tateo, Chiara Mercinelli, Davide Vignale, Stefania Rizzo, Andrea Necchi, Giovanni Peretto
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引用次数: 0

摘要

心脏毒性是几类抗癌药物的不良反应之一。在此,我们介绍了一例52岁的转移性肾细胞癌(RCC)女性患者的病例,该患者曾接受过分化手术、pembrolizumab(免疫检查点抑制剂)联合阿西替尼(酪氨酸激酶抑制剂(TKI))治疗,随后又接受了来伐替尼(TKI)和belzutifan(HIF-2α抑制剂)治疗,经心脏磁共振和心内膜活检证实,该患者出现了心肌炎。该病例的显著特点是报告了在使用贝珠替凡联合来伐替尼治疗期间发生的一种尚未描述的不良事件,其病因尚不明确,因为患者在治疗前曾接触过pembrolizumab,而pembrolizumab是药物相关性心肌炎的已知病因。我们推测,心肌炎是与pembrolizumab相关的延迟不良事件(治疗中断8个月后),但我们强调,只有在大型临床试验中对暴露于belzutifan和来伐替尼的患者的心脏不良事件进行仔细监测,才能排除这些药物的任何因果关系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Myocarditis Following Pembrolizumab Plus Axitinib, and Belzutifan Plus Lenvatinib for Renal Cell Carcinoma: A Case Report.

Myocarditis Following Pembrolizumab Plus Axitinib, and Belzutifan Plus Lenvatinib for Renal Cell Carcinoma: A Case Report.

Cardiac toxicity is an adverse event of several classes of anti-cancer drugs. Herein, we present the case of a 52-year-old woman with metastatic renal cell carcinoma (RCC), previously treated with debulking surgery, pembrolizumab (immune checkpoint inhibitor) in combination with axitinib (tyrosine kinase inhibitor (TKI)), followed by lenvatinib (TKI) and belzutifan (HIF-2α inhibitor), who developed myocarditis proven by cardiac magnetic resonance and endomyocardial biopsy. The case was notable for reporting a not-yet described adverse event during treatment with belzutifan plus lenvatinib, the etiology of which was of unobvious determination given the pre-exposure to pembrolizumab, a known cause of drug-related myocarditis. We surmise that myocarditis was a delayed adverse event related to pembrolizumab (8 months after treatment interruption), although we emphasize that only attentive monitoring of cardiac adverse events of patients exposed to belzutifan and lenvatinib in the context of large clinical trials may rule out any causal implication of these drugs.

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来源期刊
Cardiovascular Toxicology
Cardiovascular Toxicology 医学-毒理学
CiteScore
6.60
自引率
3.10%
发文量
61
审稿时长
>12 weeks
期刊介绍: Cardiovascular Toxicology is the only journal dedicated to publishing contemporary issues, timely reviews, and experimental and clinical data on toxicological aspects of cardiovascular disease. CT publishes papers that will elucidate the effects, molecular mechanisms, and signaling pathways of environmental toxicants on the cardiovascular system. Also covered are the detrimental effects of new cardiovascular drugs, and cardiovascular effects of non-cardiovascular drugs, anti-cancer chemotherapy, and gene therapy. In addition, Cardiovascular Toxicology reports safety and toxicological data on new cardiovascular and non-cardiovascular drugs.
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