{"title":"声学刺激技术对阿尔茨海默氏症患者认知功能的疗效--范围综述。","authors":"Leelavathi Thamizhmani, Kanaka Ganapathy, Hari Prakash Palaniswamy, Divya Sussana Patil, Suzanne Carolyn Purdy","doi":"10.1186/s13195-024-01544-2","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Alzheimer's disease (AD) is a progressive neurodegenerative disorder that severely affects cognitive functions and social behaviors, leading to a significant decline in an individual's quality of life. Auditory processing deficits often precede the clinical symptoms of AD, prompting interest in auditory-based interventions as potential treatments. This scoping review aimed to compile the existing evidence on active and passive auditory-based interventions for individuals with AD and its prodromal stages.</p><p><strong>Method and results: </strong>This scoping review followed Arksey and O'Malley's five-step framework to identify the existing evidence on auditory-based interventions for AD. Four databases (PubMed, Web of Science, CINAHL, and Embase) were used to search for studies on auditory stimulation techniques to treat cognitive decline in AD patients. In total, 14 studies were included in the analysis. Seven studies explored active auditory stimulation techniques, such as the Brain Fitness Program (BrainHQ), aiming to improve cognitive function in individuals with Mild Cognitive Impairment (MCI). The other seven studies focused on passive auditory stimulation, often combined with other sensory stimuli such as light or tactile inputs. Passive stimulation studies have focused mainly on Gamma Entrainment Using Sensory Stimulation (GENUS). The intervention frequency and duration varied across studies, ranging from one session lasting 8 h to a year. Both active and passive auditory stimulation showed potential for enhancing cognitive function in individuals with AD.</p><p><strong>Conclusion: </strong>The literature suggests that auditory stimulation may positively influence cortical wiring and enhance cognitive abilities. Multimodal interventions that combine auditory stimulation with other sensory or behavioural approaches could yield more substantial effects on global cognition. However, the study design, intervention characteristics and outcome measures varied across studies, underscoring the necessity for standardised reporting. Well-designed studies using standard cognitive assessment protocols are recommended.</p>","PeriodicalId":7516,"journal":{"name":"Alzheimer's Research & Therapy","volume":null,"pages":null},"PeriodicalIF":7.9000,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11293131/pdf/","citationCount":"0","resultStr":"{\"title\":\"Efficacy of acoustic stimulation techniques on cognitive functions in individuals with Alzheimer's disease-a scoping review.\",\"authors\":\"Leelavathi Thamizhmani, Kanaka Ganapathy, Hari Prakash Palaniswamy, Divya Sussana Patil, Suzanne Carolyn Purdy\",\"doi\":\"10.1186/s13195-024-01544-2\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Alzheimer's disease (AD) is a progressive neurodegenerative disorder that severely affects cognitive functions and social behaviors, leading to a significant decline in an individual's quality of life. 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The other seven studies focused on passive auditory stimulation, often combined with other sensory stimuli such as light or tactile inputs. Passive stimulation studies have focused mainly on Gamma Entrainment Using Sensory Stimulation (GENUS). The intervention frequency and duration varied across studies, ranging from one session lasting 8 h to a year. Both active and passive auditory stimulation showed potential for enhancing cognitive function in individuals with AD.</p><p><strong>Conclusion: </strong>The literature suggests that auditory stimulation may positively influence cortical wiring and enhance cognitive abilities. Multimodal interventions that combine auditory stimulation with other sensory or behavioural approaches could yield more substantial effects on global cognition. However, the study design, intervention characteristics and outcome measures varied across studies, underscoring the necessity for standardised reporting. 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引用次数: 0
摘要
背景:阿尔茨海默病(AD)是一种进行性神经退行性疾病,严重影响认知功能和社交行为,导致患者生活质量显著下降。听觉处理功能障碍往往先于老年痴呆症的临床症状出现,这促使人们将基于听觉的干预措施作为潜在的治疗方法。本范围界定综述旨在汇编现有证据,说明针对注意力缺失症患者及其前驱阶段的主动和被动听觉干预措施:本范围界定综述遵循 Arksey 和 O'Malley 的五步框架,以确定有关对注意力缺失症进行听觉干预的现有证据。我们使用了四个数据库(PubMed、Web of Science、CINAHL 和 Embase)搜索有关听觉刺激技术治疗 AD 患者认知能力下降的研究。共有 14 项研究被纳入分析。其中七项研究探讨了主动听觉刺激技术,如大脑健身计划(BrainHQ),旨在改善轻度认知障碍(MCI)患者的认知功能。其他七项研究侧重于被动听觉刺激,通常与其他感官刺激(如光或触觉输入)相结合。被动刺激研究主要集中在伽马增强感觉刺激(GENUS)。各项研究的干预频率和持续时间各不相同,从持续 8 小时的一个疗程到一年不等。主动和被动听觉刺激都显示出增强注意力缺失症患者认知功能的潜力:文献表明,听觉刺激可对大脑皮层线路产生积极影响并增强认知能力。将听觉刺激与其他感官或行为方法相结合的多模式干预可能会对整体认知能力产生更大的影响。然而,不同研究的研究设计、干预特点和结果衡量标准各不相同,这就强调了标准化报告的必要性。建议采用标准认知评估方案进行精心设计的研究。
Efficacy of acoustic stimulation techniques on cognitive functions in individuals with Alzheimer's disease-a scoping review.
Background: Alzheimer's disease (AD) is a progressive neurodegenerative disorder that severely affects cognitive functions and social behaviors, leading to a significant decline in an individual's quality of life. Auditory processing deficits often precede the clinical symptoms of AD, prompting interest in auditory-based interventions as potential treatments. This scoping review aimed to compile the existing evidence on active and passive auditory-based interventions for individuals with AD and its prodromal stages.
Method and results: This scoping review followed Arksey and O'Malley's five-step framework to identify the existing evidence on auditory-based interventions for AD. Four databases (PubMed, Web of Science, CINAHL, and Embase) were used to search for studies on auditory stimulation techniques to treat cognitive decline in AD patients. In total, 14 studies were included in the analysis. Seven studies explored active auditory stimulation techniques, such as the Brain Fitness Program (BrainHQ), aiming to improve cognitive function in individuals with Mild Cognitive Impairment (MCI). The other seven studies focused on passive auditory stimulation, often combined with other sensory stimuli such as light or tactile inputs. Passive stimulation studies have focused mainly on Gamma Entrainment Using Sensory Stimulation (GENUS). The intervention frequency and duration varied across studies, ranging from one session lasting 8 h to a year. Both active and passive auditory stimulation showed potential for enhancing cognitive function in individuals with AD.
Conclusion: The literature suggests that auditory stimulation may positively influence cortical wiring and enhance cognitive abilities. Multimodal interventions that combine auditory stimulation with other sensory or behavioural approaches could yield more substantial effects on global cognition. However, the study design, intervention characteristics and outcome measures varied across studies, underscoring the necessity for standardised reporting. Well-designed studies using standard cognitive assessment protocols are recommended.
期刊介绍:
Alzheimer's Research & Therapy is an international peer-reviewed journal that focuses on translational research into Alzheimer's disease and other neurodegenerative diseases. It publishes open-access basic research, clinical trials, drug discovery and development studies, and epidemiologic studies. The journal also includes reviews, viewpoints, commentaries, debates, and reports. All articles published in Alzheimer's Research & Therapy are included in several reputable databases such as CAS, Current contents, DOAJ, Embase, Journal Citation Reports/Science Edition, MEDLINE, PubMed, PubMed Central, Science Citation Index Expanded (Web of Science) and Scopus.