以离子液体修饰的金属有机框架为固定相的微型气相色谱柱用于胃癌的快速呼气分析

Guoqiang Hu, Zihao Wang, Feifei Yan, Hairong Wang, Xinyuan Hua, Kangning Zhang, Jialing Gao, Pengyu Dong, Shengbin Li, Cheng Cheng
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引用次数: 0

摘要

制备了用于胃癌快速呼气分析的微型气相色谱柱(μGCs)。研究了比表面积和孔径对分离能力的协同作用。以[P66614][Cl]/UIO-66为固定相制备了μGC-IL/UIO-66。为了进行比较,分别使用[P66614][Cl]和 UIO-66 作为固定相制备了 μGC-IL 和 μGC-UIO-66 。[P66614][Cl]/UIO-66具有高比表面积,孔径分布为0.49 nm。[P66614][Cl]/UIO-66的高比表面积提高了吸附和解吸的效率,而适当孔径的多孔结构则起到了高效分子筛的作用,协同提高了分离效率。因此,与 μGC-IL 和 μGC-UIO-66 相比,μGC-IL/UIO-66 的 HETP 分别降低了 68.2% 和 22.6%。在分析胃癌的挥发性生物标记物(丙酮、苯、正己烷和甲苯)时,相邻峰之间的分辨率分别为 1.96、2.13 和 3.67,符合定量分析的要求(R > 1.5)。丙酮、苯、正己烷和甲苯的保留时间分别为 0.72 分钟、0.96 分钟、1.33 分钟和 1.67 分钟,可以进行快速分析。所有这些都表明,μGC-IL/UIO-66 在快速呼气分析胃癌方面具有广阔的应用前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Micro gas chromatography column using ionic liquid modified metal-organic framework as stationary phase for rapid breath analysis of gastric cancer
The micro gas chromatography columns (μGCs) were prepared for rapid breath analysis of gastric cancer. The synergistic effect of the specific surface area and the action of pore diameter on the separation capacity was investigated. The μGC-IL/UIO-66 was prepared using [P66614][Cl]/UIO-66 as the stationary phase. For comparison, the μGC-IL and the μGC-UIO-66 were prepared using [P66614][Cl] and UIO-66 as stationary phase, respectively. [P66614][Cl]/UIO-66 had a high specific surface area with a pore diameter distribution of 0.49 nm. The high specific surface area of [P66614][Cl]/UIO-66 improved the efficiency of adsorption and desorption, while the porous structure with an appropriate pore diameter acted as an efficient molecular sieve, synergistically enhancing separation efficiency. So compared to the μGC-IL and the μGC-UIO-66, the HETP of μGC-IL/UIO-66 was reduced by 68.2% and 22.6%, respectively. In the analysis of volatile biomarkers (acetone, benzene, n-hexane and toluene) for gastric cancer, the resolutions between adjacent peaks were 1.96, 2.13 and 3.67, which met the requirements for quantitative analysis (R > 1.5). The retention times of acetone, benzene, n-hexane and toluene were 0.72 min, 0.96 min, 1.33 min and 1.67 min, which enables rapid analysis. All may suggest that the μGC-IL/UIO-66 has a promising application in rapid breath analysis of gastric cancer.
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