Omotayo Fatokun, Malarvili Selvaraja, Haryati Anuar, T. Jamaluddin, Sharifah Norkhadijah Syed Ismail, R. Mansor, Shamsul Azhar Shah, Nelson Oranye
{"title":"人类-动物-环境界面的抗菌药耐药性:聚焦耐抗菌性大肠杆菌的传播动态、临床影响和未来方向","authors":"Omotayo Fatokun, Malarvili Selvaraja, Haryati Anuar, T. Jamaluddin, Sharifah Norkhadijah Syed Ismail, R. Mansor, Shamsul Azhar Shah, Nelson Oranye","doi":"10.14202/ijoh.2024.161-171","DOIUrl":null,"url":null,"abstract":"Understanding and combating antimicrobial resistance (AMR) is increasingly centered on the intricate relationship between humans, animals, and the environment, with Escherichia coli being the main source of AMR-related fatalities worldwide. E. coli, though prevalent in the intestines of humans and warm-blooded creatures, demonstrates wide ecological adaptability in both intestinal and extraintestinal habitats. This study explores the dynamics, implications, and future directions of antimicrobial-resistant E. coli (AREC) transmission and clinical significance. We investigated the spread of antibiotic-resistant strains among humans, animals, and the environment, illuminating the impact of healthcare and agriculture practices, as well as environmental contamination. The implications of AREC infections are addressed, emphasizing the challenges in treatment due to limited antibiotic options, increased morbidity and mortality rates, and economic burdens on healthcare systems and agriculture, as well as the urgent need for a One Health approach to combat AMR through collaborative efforts across disciplines. Proposed future directions encompass enhanced surveillance, innovative antimicrobial stewardship, and alternative treatment modalities.\n\nKeywords: antimicrobial stewardship, antimicrobial-resistant Escherichia coli, clinical implications, One Health, surveillance strategies, transmission dynamics.","PeriodicalId":37300,"journal":{"name":"International Journal of One Health","volume":"28 8","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Antimicrobial resistance at the human–animal–environment interface: A focus on antimicrobial-resistant Escherichia coli transmission dynamics, clinical implications, and future directions\",\"authors\":\"Omotayo Fatokun, Malarvili Selvaraja, Haryati Anuar, T. Jamaluddin, Sharifah Norkhadijah Syed Ismail, R. Mansor, Shamsul Azhar Shah, Nelson Oranye\",\"doi\":\"10.14202/ijoh.2024.161-171\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Understanding and combating antimicrobial resistance (AMR) is increasingly centered on the intricate relationship between humans, animals, and the environment, with Escherichia coli being the main source of AMR-related fatalities worldwide. E. coli, though prevalent in the intestines of humans and warm-blooded creatures, demonstrates wide ecological adaptability in both intestinal and extraintestinal habitats. This study explores the dynamics, implications, and future directions of antimicrobial-resistant E. coli (AREC) transmission and clinical significance. We investigated the spread of antibiotic-resistant strains among humans, animals, and the environment, illuminating the impact of healthcare and agriculture practices, as well as environmental contamination. The implications of AREC infections are addressed, emphasizing the challenges in treatment due to limited antibiotic options, increased morbidity and mortality rates, and economic burdens on healthcare systems and agriculture, as well as the urgent need for a One Health approach to combat AMR through collaborative efforts across disciplines. Proposed future directions encompass enhanced surveillance, innovative antimicrobial stewardship, and alternative treatment modalities.\\n\\nKeywords: antimicrobial stewardship, antimicrobial-resistant Escherichia coli, clinical implications, One Health, surveillance strategies, transmission dynamics.\",\"PeriodicalId\":37300,\"journal\":{\"name\":\"International Journal of One Health\",\"volume\":\"28 8\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of One Health\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.14202/ijoh.2024.161-171\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"Veterinary\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of One Health","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.14202/ijoh.2024.161-171","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Veterinary","Score":null,"Total":0}
引用次数: 0
摘要
了解和抗击抗菌药耐药性(AMR)越来越多地集中在人类、动物和环境之间错综复杂的关系上,而大肠埃希氏菌则是全球与抗菌药耐药性相关的死亡病例的主要来源。大肠杆菌虽然普遍存在于人类和温血动物的肠道中,但在肠内和肠外栖息地都表现出广泛的生态适应性。本研究探讨了耐抗生素大肠杆菌(AREC)传播的动态、影响和未来方向以及临床意义。我们调查了耐抗生素菌株在人类、动物和环境中的传播情况,揭示了医疗保健和农业实践以及环境污染的影响。我们探讨了 AREC 感染的影响,强调了由于抗生素选择有限、发病率和死亡率上升、医疗保健系统和农业的经济负担而带来的治疗挑战,以及通过跨学科合作来对抗 AMR 的 "一体健康 "方法的迫切需要。建议的未来方向包括加强监测、创新抗菌药物管理和替代治疗模式。关键词:抗菌药物管理、抗菌性大肠埃希菌、临床影响、"一体健康"、监测策略、传播动态。
Antimicrobial resistance at the human–animal–environment interface: A focus on antimicrobial-resistant Escherichia coli transmission dynamics, clinical implications, and future directions
Understanding and combating antimicrobial resistance (AMR) is increasingly centered on the intricate relationship between humans, animals, and the environment, with Escherichia coli being the main source of AMR-related fatalities worldwide. E. coli, though prevalent in the intestines of humans and warm-blooded creatures, demonstrates wide ecological adaptability in both intestinal and extraintestinal habitats. This study explores the dynamics, implications, and future directions of antimicrobial-resistant E. coli (AREC) transmission and clinical significance. We investigated the spread of antibiotic-resistant strains among humans, animals, and the environment, illuminating the impact of healthcare and agriculture practices, as well as environmental contamination. The implications of AREC infections are addressed, emphasizing the challenges in treatment due to limited antibiotic options, increased morbidity and mortality rates, and economic burdens on healthcare systems and agriculture, as well as the urgent need for a One Health approach to combat AMR through collaborative efforts across disciplines. Proposed future directions encompass enhanced surveillance, innovative antimicrobial stewardship, and alternative treatment modalities.
Keywords: antimicrobial stewardship, antimicrobial-resistant Escherichia coli, clinical implications, One Health, surveillance strategies, transmission dynamics.
期刊介绍:
International Journal of One Health publishes high quality and novelty papers focusing on One Health. Review articles are highly appreciated. All articles published by International Journal of One Health are made freely and permanently accessible online. All articles to International Journal of One Health are posted online immediately as they are ready for publication.